<![CDATA[Introduction: Parkinson’s disease is the second most common neurodegenerative disorder with motor and nonmotor symptoms. The manifestations of Parkinson’s disease evolve in morbidity and quality of life (QOL) reduction. QOL is an essential measurement for Parkinson’s disease, one of the instruments has been used in Parkinson’s Disease Questionnaire-39 (PDQ-39). Aim: To recognize factors affecting QOL of patients with Parkinson’s using PDQ-39. Methods: This study was an observational analytic study, cross-sectional design, carried out on Parkinson’s patients, conducted at Mohammad Hoesin, Pusri and Bhayangkara Hospital from 1 June to 30 September 2020. Data was collected using the PDQ-39 questionnaire, Non-Motor Symptoms Questionnaire (NMSQ), Mini-Mental State Examination (MMSE). Moreover, this study also assessed the degree of disease severity with the Hoehn and Yahr Scale. Results: There were 52 subjects with a mean of age 65.13±10.28 years, and the majority were over 60 years (69.2%), male (55.????%), and had stage III disease severity (59.6%), with disease duration ≥5 years (63.5%). There were 59.6% patients with good QOL and 40.4% with poor QOL. We found that the disease’s stage (p=0.009), duration (p=0.006), and sensory symptoms (p=0.014) had a significant effect on the patient's QOL based on bivariate analysis. Furthermore, multivariate logistic regression analysis showed that the disease’s stage (p=0.029; OR=3.186) and sensory symptoms (p=0.070; OR=3.771) had the most significant effect on the Parkinson's QOL. Discussion: The factors affecting the QOL of patients with Parkinson’s were the disease’s stage, duration, and sensory symptoms. Key words: Parkinson’s disease, PDQ-39, quality of life]]>
