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All Journal Majalah Kesehatan FKUB Neurona
Dessika Rahmawati
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Health Professions Medicine & Pharmacology Neuroscience Public Health

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FAKTOR-FAKTOR YANG BERPENGARUH PADA PROGNOSIS PASIEN TUMOR OTAK METASTASIS DI RSUD SAIFUL ANWAR MALANG Dotti Inggrianita; Dessika Rahmawati; Rodhiyan Rakhmatiar; Nuretha Hevy Purwaningtyas
NEURONA Vol 39 No 1 (2021)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.276

Abstract

ABSTRACT Introduction: Metastatic brain tumor is a critical period for the spread of malignancy originating from other organs. This type of tumor is the most common intracranial tumor. Prognosis for metastatic brain tumors is poor. Karnofsky Performance scale is an assessment of performance status which can be used to know prognosis of patients with brain tumors. Aim To determine the factors that influence the prognosis of metastatic brain tumor patients in Saiful Anwar General Hospital. Methods: The design of this study was cross sectional retrospective. Data were taken based on patient’s characteristics, clinical, radiological factors, primary tumor type and comorbidities from Neurooncology register data in RSUD dr. Saiful Anwar Malang during January 2017 to December 2020. The data were presented in descriptive and analytic using multivariate logistic regression. Result: There were 71 subjects with metastatic brain tumors and had the same proportion of males and females. Based on the assessed factors, there were two variables that significantly correlated. Age <60 years had a correlation with Karnofsky Performance Scale <60 (p: 0.012) (OR: 0.076). Decreased consciousness had a significant correlation with poor prognosis, that is Karnofsky Performance Scale <60 (p: 0.021) (OR: 13.851). Discussions: Factors affected prognosis of metastatic brain tumor in saiful anwar general hospital malang Age < 60 years and altered mental state affect prognosis of patients with metastatic brain tumor in Saiful Anwar General Hospital. Age < 60 years is a good prognosis while decreased of consciousness shows the poor prognosis. Keywords: Karnofsky performance scale, metastatic brain tumor, prognosis.
LATE-PRESENTING NEUROFIBROMATOSIS TYPE 1 COMPLICATED BY MALIGNANTTRANSFORMATION AND MULTIORGAN METASTASIZE: A RARE CASE REPORT Dhiya' Fathiyyah Zen; Intan Dwikarlina; Dessika Rahmawati
Majalah Kesehatan Vol. 0 No. 00 (2026): Article in Press
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Neurofibromatosis 1 (NF-1) is a rare genetic disorder characterized by a risk of benign and malignant tumors. NF-1 usually arises in childhood. Hence, the incidence of adult-onset NF-1 is important to further discuss. This case report aims to describe the clinical presentation and advanced complications in a 59-year-old patient with suspected neurofibromatosis Type 1 presenting with decreased consciousness and pathological fractures associated with metastatic progression. We report a 59-year-old woman presenting with a gradual loss of consciousness for two months, left arm pain for three months, and a history of multiple lumps and café-au-lait spots since childhood. Physical examination revealed delirium, multiple neurofibromas, freckles, and a fracture of the left humerus. Imaging later demonstrated metastases to the brain, lungs, and bones. This case highlights the malignant potential of NF-1-associated tumors in adults, particularly the risk of multi-organ metastases in long-standing lesions. Diminished level of consciousness may occur due to the transformation of the tumor to malignant, resulting in metastases to the brain. Lung metastases can be identified on radiological findings as nodules. Long bone dysplasia will enhance the risk of pathological fractures in NF-1 patients. Examination of tumor markers, radiology, and histopathology is necessary for diagnosis. Early recognition, vigilant monitoring, and multidisciplinary management are essential to optimize outcomes and prevent fatal complications.
Co-Authors Dhiya' Fathiyyah Zen Dotti Inggrianita Intan Dwikarlina Nuretha Hevy Purwaningtyas Rodhiyan Rakhmatiar