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All Journal MEDICINUS Neurona
Elvan Wiyarta
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PENGARUH VARIASI SNP TERHADAP RISIKO KEJADIAN MENINGIOMA: SEBUAH TELAAH SISTEMATIS DAN META ANALISIS Elvan Wiyarta
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.316

Abstract

Meningiomas are the most common type of extraaxial intracranial neoplasm. Along with the development of genomics, several studies have begun to examine the association of meningioma occurrence with the presence of single-nucleotide polymorphisms (SNPs). This study aims to examine the relationship between SNP and the risk of meningioma. Literature searches were carried out on various databases which were then collected, reviewed, and assessed for eligibility criteria. From the search results, obtained 7 studies to be analyzed statistically. The results of grouping these studies showed that 3 SNPs (rs1801133, rs1805087, and rs4968451) in 3 genes (MTHFR, MTR, and BRIP1) were associated with meningioma risk. Of the 3 SNPs, only rs1801133 aa had a significant association with meningioma risk (pooled OR [95%CI]: 2.32 [1.34-4.02]). This shows that mutations in the MTHFR gene in the SNP rs1801133 in both alleles (aa) cause a person to have a 2.32 times greater risk of developing meningioma than people who do not have this SNP. Keyword: meningiomas; SNPs; genome-wide association study; risk factors; bioinformatics
Nutritional Intervention in Osteoporosis: An Overlooked Management in Primary Care Muhammad Gifari Rasyidi; Mohammad Wibowo Ariyanto; Ahmad Fakar Sanusi Rasyid; Elvan Wiyarta
MEDICINUS Vol. 38 No. 3 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/9fh08k72

Abstract

Osteoporosis is a bone disease with a high global mortality rate. Typically, it affects adults and the elderly, particularly postmenopausal women. Normally, bone thinning and decreased bone mineral density are consequences of aging. Osteoporosis leads to significant decrease in quality of life and an increase in the incidence of fractures. In this condition, bone formation and resorption must be in balance for optimal bone remodeling. Numerous factors affect this mechanism, but one has frequently been overlooked: the deficiency of nutrients such as vitamin D, calcium, and other micronutrients that could help maintaining healthy bone remodeling. The effect of nutrition on bone formation and the prevention of bone loss is synergistic. Therefore, supplementation and nutritional sufficiency monitoring in individuals at risk for osteoporosis can be one prudent action. Most therapeutic focus in Indonesia remains exclusively concentrated on curative pharmacotherapy. This article aims to review the existing literature on nutritional interventions to prevent and slow the progression of the disease, as well as raising awareness regarding the urgency to take preventive measures in osteoporosis management.
Co-Authors Ahmad Fakar Sanusi Rasyid Mohammad Wibowo Ariyanto Muhammad Gifari Rasyidi