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Purnamawati Purnamawati
Departemen Histopatologi Anatomi, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Krida Wacana, Jakarta, Indonesia.
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Prevalensi Tumor Payudara di RS Hermina Daan Mogot pada Tahun 2017-2021 Febrina Githa Agatha; Shintia Christina; Purnamawati Purnamawati
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v2i1.2708

Abstract

Breast cancer is the number one cause of death in developing countries. The purpose of this study was to determine the prevalence and characteristics of breast tumor patients based on histopathological examination at Hermina Daan Mogot Hospital in 2017-2021. This research is an observational descriptive cross-sectional technique regarding breast tumors with parameters such as age, clinical diagnosis and histopathological diagnosis.. In this study, 716 subjects met the inclusion and exclusion criteria. histopathological diagnosis with the most results of mammary carcinoma at the age of 40-49 (40.86%) and the most histopathological diagnosis of fibroadenoma mammary at the age of 20-29 (37.35%). The most common clinical diagnosis consistent with the histopathological diagnosis is fibroadenoma mammary, which is part of a fibroepithelial tumor. The least common clinical diagnosis was papilloma (0.4%) and the least clinical diagnosis was papillary lesion (0.3%), where the papilloma was part of the papillary lesion. Early breast examination is needed to be able to detect malignant lesions at an early stage so that appropriate management can be carried out immediately so as to increase the patient's life expectancy.
Manfaat Pemeriksaan Biomarker B-Rapidly Accelerated Fibrosarcoma (BRAF) pada Pasien Preoperatif dengan Kanker Tiroid Edvano Adam Herbudi; Fanny Indarto; Purnamawati Purnamawati
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v2i1.2811

Abstract

Thyroid cancer is the most common cancer of the endocrine system. In the detection of thyroid cancer, the gold standard examination is using fine-needle aspiration (FNA), where the cytology results are used in 60% - 80% of cases. FNA examination performed preoperatively determine the initial management of thyroid cancer. However, the FNA technique is limited by insufficient samples in about 2% - 20% of cases and about 10% - 30% of FNA results are classified as indeterminate (ITN) in the Bethesda system. Therefore, molecular tests such as BRAF biomarker screening are expected to help improve the detection of cases in this category. Methods: A literature search conducted from 4 databases (PubMed, ProQuest, ScienceDirect, and Google Scholar) published in the last 10 years with the keywords "preoperative", "braf" or "braf kinases", and "thyroid cancer". Results: Ten studies with total of 11,239 specimens classified in Bethesda III - VI showed increased sensitivity of 34.8% - 96.62% in the combination of FNA and BRAF techniques. Conclusion: The combination of preoperative FNA and BRAF examination increase sensitivity and help in the initial management of thyroid cancer in ITN or Bethesda III and IV group thyroid nodules in the detection of malignancy in the thyroid.
Co-Authors Edvano Adam Herbudi Fanny Indarto Febrina Githa Agatha Shintia Christina