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Santi Anugrahsari
Departemen Mata, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Kristen Krida Wacana, Jakarta, Indonesia.
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Potential of Adeno-associated virus Vector Gene Therapy for Achromatopsia Farianti Wiranda; Grace Marta Tanjung; Yudha Pandapotan; Santi Anugrahsari
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2828

Abstract

Achromatopsia, also known as color blindness, is the inability to distinguish certain colors. Where this is the inability of the eye cone cells to capture a certain color spectrum due to genetic factors and certain diseases. Abnormalities in the anatomical structure of the eye located on the retina and inherited recessively. These mutations lead to functional loss and slowly progressive degeneration of the cone photoreceptors. Treatment for color blindness is currently limited to genetic counseling, glasses or colored contact lenses. Genetic therapy methods are currently being developed targeting the retinal organs using recombinant adenovirus vectors. The results of research conducted on animals found an improvement in the function of cone cells so that gene therapy is a promising modality in the future.
Efektivitas Obat Tetes Mata Sodium Hialuronat Pada Dry Eye Disease Grace Raveena Widelia Worumi; Jois Mauren Lumantobing; Michael Usup; Santi Anugrahsari
Jurnal MedScientiae Vol. 2 No. 3 (2023): Desember
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2875

Abstract

Dry eye disease (DED) or keratoconjunctivitis sicca is a multifactorial disease of the ocular surface characterized by loss of tear film homeostasis, inflammation and damage to the ocular surface as well as neurosensory abnormalities with symptoms such as the sensation of a foreign body in the eye, dry eyes, irritation, itching and sensitivity to light, which can impact a patient's daily activities and life.  The prevalence of DED is between 5% and 50% in the adult population which can be caused by factors such as female, cataract surgery, use of contact lenses, computers, thyroid disorders, hypertension, and use of antihistamines and antidepressants. One of the DED therapies is the provision of artificial tears where polymers such as hyaluronic acid can be used because they can increase tear volume and eye moisture.  This literature review was made with the aim of knowing the effectiveness of sodium hyaluronate eye drops in treating dry eye disease. 8 journals were selected through the PubMed, ProQuest and Google Scholar journal databases and then presented in the form of a literature review. Based on the analysis results, sodium hyaluronate eye drops are effective in relieving dry eye symptoms.
Peran Vitamin D dalam Retinopati Diabetik Michelle Amelia Tanian; Felix Rowan; Santi Anugrahsari; Rendy Damar Nugraha
Jurnal MedScientiae Vol. 2 No. 3 (2023): Desember
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2919

Abstract

Diabetic retinopathy (RD) is the most common microvascular complication and can cause visual impairment and even blindness. Various studies show a relationship between vitamin D deficiency and increased incidence of RD. The purpose of this scientific paper is to explore the role of vitamin D in relation to RD so as to open opportunities for further knowledge and research. Research Methods using Literature Review, by searching PubMed and Google Scholar, with keywords in English "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" and "diabetic retinopathy". In the discussion it was discussed that vitamin D plays a protective role in the development of diabetic retinopathy through its anti-inflammatory and anti-angiogenic properties. For future research, it is hoped that it will further explore the role of Vitamin D in relation to Diabetic retinopathy.
Co-Authors Farianti Wiranda Felix Rowan Grace Marta Tanjung Grace Raveena Widelia Worumi Jois Mauren Lumantobing Michael Usup Michelle Amelia Tanian Rendy Damar Nugraha Yudha Pandapotan