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Arini Astasari Widodo
Departemen Dermatologi dan Venereologi, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Krida Wacana, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effectiveness of Spironolactone for Acne Vulgaris Wong Hendra Wijaya; Arini Astasari Widodo; Chearin Dea Sanfika
Jurnal MedScientiae Vol. 2 No. 2 (2023): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i2.2956

Abstract

Acne vulgaris is a skin disease that attacks pilosebaceous follicles which can be either inflammatory or non-inflammatory lesion. One of the important factors causing acne vulgaris is androgen hormone. One of the hormonal therapies that can be given for acne vulgaris is spironolactone which has a function as an antiandrogen. The purpose of writing this literature review is to determine the effectiveness, mode of action, indications, contraindications, and side effects of spironolactone in the treatment of acne vulgaris. The method in making this final project is Literature Review. Literature searches were obtained using electronic databases such as Google Scholar, PubMed, Proquest, International Journal of Women's Dermatology, and NCBI. The keywords used were spironolactone, hormonal therapy, acne vulgaris, effectiveness of spironolactone for acne vulgaris. There are 10 supporting journals based on the suitability of topics in the last 10 years. The results showed that the administration of spironolactone for acne vulgaris proved to be effective with an average dose of 50-100 mg/day which resulted in 70-90% clinical improvement and caused minimal side effects. Spironolactone has good effectiveness and tolerability for alternative therapy of acne vulgaris in adult women and for patients who do not respond well to conventional therapy.
Some Risk Factors of Atopic Dermatitis in Adults Wong Hendra Wijaya; Arini Astasari Widodo; Fitria Jaya
Jurnal MedScientiae Vol. 2 No. 3 (2023): Desember
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.3038

Abstract

Atopic dermatitis (AD) is an inflammatory skin disorder characterized by intense itching and eczematous lesions. The onset of AD usually occurs in childhood and AD symptoms can last into adulthood. An increasing prevalence of AD has been observed worldwide. The causes of AD are multifactorial and there are still not many systematic reviews of AD-related risk factors. This study uses a literature review method. Literature search was conducted using Google Scholar and PubMed. using keywords: atopic dermatitis, risk factors, adults, and observational studies. All literature was selected using inclusion and exclusion criteria to assess the suitability of the content and quality of the study. Patients with atopic dermatosis had a filaggrin mutation cause loss/change in the function of filaggrin (Filament Aggregating Protein). Risk factors for atopic dermatitis in adults include a history of atopy, food allergies, a history of atopy in the father or mother or both, history of AD in parents, having pets at home, younger age or early onset, being a former smoker, gender women and active smoking, as well as passive smokers, low education level (<=12 years), socioeconomic status, and living in small places. Symptoms and clinical manifestations include pruritus, morphology and wide distribution of lesions, chronic and recurrent dermatitis, history of atopy and family history of atopy. Management of atopic dermatitis begins with education and skin care by taking regular baths and using emollients/moisturizers. Atopy and family history of atopy, smoking, low education, and socioeconomic are risk factors for AD in adults.
Co-Authors Chearin Dea Sanfika Fitria Jaya Wong Hendra Wijaya