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All Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Jurnal Riset Kefarmasian Indonesia
Masniah
Politeknik Kesehatan Kementerian Kesehatan Medan
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Potential Antifungal of Merang Padi Extract (Oryza sativa) Against Fungal Growth Masniah Masniah; Ahmad Purnawarman Faisal
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 6, No 1 (2024): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v6i1.19288

Abstract

Merang padi is a traditional medicine that comes from natural ingredients, namely plants. However, there has not been much research on the activity of rice straw extract (Oryza sativa) being explored and researched. The aim of this research was to determine the yield of extracts and the number of antifungal isolates in inhibiting fungal growth and their potential as antifungals against Candida albicans and Aspergillus fumigatus fungi. This research uses experimental research with a quantitative approach carried out through laboratory tests. The design used was a Completely Randomized Design (CRD) which was grouped into 6 treatment groups, namely 4 groups of rice straw extract and 2 control groups which were repeated for each treatment 4 times. The treatment group consisted of P1 with rice straw extract with a concentration of 20,000 ppm, P2 with rice straw extract with a concentration of 40,000 ppm, P3 with rice straw extract with a concentration of 60,000 ppm and P4 with rice straw extract with a concentration of 80,000 ppm. Meanwhile, the control group, namely P0 as a negative control, namely NaCl 0.9% and P5 as a positive control, namely Nystatin 100,000 IU. The research sample was rice straw from rice plants that had been identified and then weighed. Data analysis used one way ANOVA SPSS version 20. If there were differences then a further test was carried out, namely the Honest Significant Difference Test (BNJ) to see the differences between each treatment based on the coefficient of diversity (KK) value obtained at the 5% test level. The results of tests that have been carried out show that the n-hexane fraction of rice straw has no antifungal activity, while the ethyl acetate and n-butanol fractions have antifungal activity. The concentration of ethyl acetate in this study was greater than the other compounds. Keywords : Candida albicus, merang padi, mushrooms, oryza sativa
ISOLASI SENYAWA AKTIF DAN UJI AKTIVITAS EKSTRAK JAHE MERAH (ZINGIBER OFFICINALE) SEBAGAI IMUNOMODULATOR Masniah Masniah; Jafril Rezi; Ahmad Purnawarman Faisal
Jurnal Riset Kefarmasian Indonesia Vol. 3 No. 2 (2021): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v3i2.131

Abstract

Red ginger (Zingiber officinale) contains many chemical compounds that have many activities. This study aims to determine the active compounds of Zingiber officinale and immunomodulatory activity that can increase the phagocytosis of macrophage cells and lymphocyte cell proliferation. Red ginger extract compounds were identified using GC-MS. The parameters of immunostimulatory activity were macrophage phagocytosis and lymphocyte proliferation, the preparations were made in several extract concentrations. This research is an experimental study in the laboratory. The research included fresh red ginger, made into ethanol extract, dried. The results were made a suspension, the extract was then given to macrophage cells (phagocytosis testing) and lymphocyte cells (proliferation testing) in vitro to test the immunomodulatory effect. The results showed that the most active extract in macrophage phagocytosis activity was the extract concentration of 500 ppm. While the activity of lymphocyte proliferation was shown by the concentration of group A (Cell, 500 ppm extract, MK, Engerik). The active compound contained in the ethanol extract of red ginger is thought to be Geraniol
Co-Authors Ahmad Purnawarman Faisal Ahmad Purnawarman Faisal Jafril Rezi