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All Journal Borneo Journal of Pharmacy Community Research and Application Journal (CRAJ)
Munawarohthus Sholikha
Institut Sains dan Teknologi Nasional
Environmental Science Medicine & Pharmacology Social Sciences

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Tyrosinase Inhibition Activity and Phytochemical Screening of Melaleuca leucadendron L. Leaves Munawarohthus Sholikha; Ainun Wulandari
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3694

Abstract

Melaleuca leucadendron L. is a plant whose almost all parts (bark, leaves, twigs, and fruit) can be used as medicine, such as antioxidants, antifungals, sedative effects, and anti-hyaluronidase. This research was conducted to determine tyrosinase inhibition activity and compound content of M. leucadendron leaves. Maceration of M. leucadendron leaves was done in methanol, then carried out liquid-liquid fractionation with n-butanol, chloroform, and water. Methanol extract, butanol fraction, chloroform fraction, and water fraction were tested for phytochemical screening and tyrosinase inhibition using L-DOPA substrate with an ELISA plate well reader. The results of the tyrosinase inhibition activity test at concentrations of 100, 1000 and 10000 μg/mL respectively showed that methanol extract 29.532%, 55.227%, 89.583%; butanol fraction 29.313%, 59.174%, 94.737%, chloroform fraction 21.820%, 24.671%; 53.765%; water fraction 24,086%, 47.661%, 91.118%. Inhibition of the tyrosinase enzyme is shown through the IC50 value from methanol extract, butanol fraction and water fraction, and kojic acid as a positive control, respectively 645.438 μg/mL, 517.935 μg/mL, 669.403 μg/mL, 50.064 μg/mL. Phytochemical screening showed that the extract and fraction contained tannins, flavonoids, saponins, terpenes, and steroids. These results indicate that the butanol fraction is more potent as an anti-tyrosinase agent than the others.
Health Screening: Blood Glucose, Blood Pressure, and Body Composition Examination in RT 005 RW IV, Kelurahan Gondoriyo, Ngaliyan, Semarang Qisthi Fariyani; Irman Said Prastyo; Heni Sumarti; Sheilla Rully Anggita; Moch Husain; Delia Okta Rahmadani1; Munawarohthus sholikha
Community Research and Application Journal (CRAJ) Vol. 2 No. 2 (2026): June
Publisher : Konsorsium Pengetahuan Innoscientia (KOPINNOS)

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Abstract

Non-communicable diseases (NCDs) such as diabetes mellitus, hypertension, and obesity remain a major public health burden in Indonesia. National data (Riskesdas, 2018) reported a hypertension prevalence of 34.1% among Indonesian adults and a diabetes mellitus prevalence of 10.9% among the population aged 15 years and above, with many cases undetected because these conditions are often asymptomatic in their early stages. This community health screening was carried out on Sunday, 14 June 2026, at Beringin Forest Park, Kelurahan Gondoriyo, Kecamatan Ngaliyan, Semarang, as part of the community service program of the Department of Physics, Universitas Islam Negeri Walisongo Semarang. The activity provided free examination of blood glucose (capillary method), blood pressure (digital tensimeter), and body composition (bioelectrical impedance analysis), together with education on the procedures and individual consultation for participants with abnormal findings. Of 16 participants screened for blood glucose, 81.3% (13 participants) fell within the normal range, while one participant (6.3%) recorded a value in the diabetes range requiring immediate medical evaluation. Of 17 participants screened for blood pressure, only 23.5% (4 participants) had normal blood pressure, whereas 70.6% (12 participants) fell into the Hypertension Stage 1 or Stage 2 category. Mean body fat percentage exceeded normal reference ranges for both female (34.3%, n = 11) and male (24.3%, n = 4) participants. These findings indicate a considerable burden of undetected cardiometabolic risk factors within this community and demonstrate the value of low-cost, university–community screening partnerships for early detection and referral. Given the limitations of single-visit measurement, confirmatory examination by authorized medical personnel is recommended for participants with abnormal results.
Co-Authors Ainun Wulandari Delia Okta Rahmadani1 Fariyani, Qisthi Moch Husain Prastyo, Irman Said Sheilla Rully Anggita Sumarti, Heni