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Ruby Setiawan
National Research and Innovation Agency, Jalan Raya Bogor KM46, Cibinong, 16911, Bogor, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Diagnostic Value of Saliva RT-PCR Test within Suspected SARS-CoV-2 Cases in Indonesia Andika Chandra Putra; Jamal Zaini; Asep Muhammad Ridwanuloh; Herjuno Ari Nugroho; Ryan Haryo Setyawan; Idris Idris; Ruby Setiawan; Pangda Sopha Sushadi; Ari Sulistyo Wulandari; Anky Zannati; Indriawati Indriawati; Eva Erdayani; Wahyuni Wahyuni; Dian Fitria Agustiyanti; Popi Hadi Wisnuwardhani; Zahrah Saniyyah; Wira Norman Azika; Budi Haryanto; Ahmad Rusdan Handoyo Utomo; Ratih Asmana Ningrum
Health and Medical Journal Vol 6, No 2 (2024): HEME May 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i2.1494

Abstract

Introduction: The ongoing SARS-CoV-2 pandemic has profoundly emphasized the pressing need for accurate and reliable diagnostic procedures. Given the potential health risks associated with nasopharyngeal swabs, there has been growing interest in seeking alternative diagnostic mediums. In this context, our study delved into evaluating saliva as a potential diagnostic tool, simultaneously assessing its efficiency in relation to patient demographics and their exhibited clinical symptoms. Methods: Spanning from May to December 2020, we conducted a comprehensive cross-sectional analysis. We meticulously examined medical records to gather insights on patient characteristics, existing health conditions, onset of symptoms, clinical manifestations, and compared the results obtained from both salivary and nasopharyngeal RT-PCR tests for SARS-CoV-2. Results: Among the individuals suspected of SARS-CoV-2 infection, the mean age stood at 52.4 years, with males representing 60.3% of this group. Interestingly, a significant 76.9% reported underlying health conditions, predominantly hypertension and diabetes. The most commonly reported symptoms encompassed respiratory challenges, notably coughing and shortness of breath, succeeded by symptoms like nausea, fever, and a general sense of fatigue. The performance of saliva tests, in terms of accuracy, appeared to be significantly influenced by the timing of symptom emergence. Conclusion: The RT-PCR tests utilizing saliva samples demonstrated considerable promise, especially during the early stages of symptom manifestation, providing a reliable alternative to traditional nasopharyngeal swabs. The findings suggest a superior diagnostic sensitivity when utilizing saliva during the initial phases of a SARS-CoV-2 infection.
Co-Authors Ahmad Rusdan Handoyo Utomo Anky Zannati Ari Sulistyo Wulandari Asep Muhammad Ridwanuloh Budi Haryanto Dian Fitria Agustiyanti Eva Erdayani Herjuno Ari Nugroho Idris Idris Indriawati Indriawati Pangda Sopha Sushadi Popi Hadi Wisnuwardhani Putra, Andika Chandra Ratih Asmana Ningrum Ryan Haryo Setyawan Wahyuni Wahyuni Wira Norman Azika Zahrah Saniyyah Zaini, Jamal