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All Journal International Journal of Health Science and Technology KOLONI
Yani Sodiqah
Universitas Muslim Indonesia
Humanities Civil Engineering, Building, Construction & Architecture Engineering Health Professions Law, Crime, Criminology & Criminal Justice Nursing Public Health Social Sciences Other

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Literature Review : Efektivitas Antimikroba Kulit Manggis (Garcinia Mangostana L.) terhadap Cutibacterium Acnes dan Staphylococcus Epidermidis Waode Afiqah Muyyasarah Nur Bahrani; Dian Amelia Abdi; Zulfiyah Surdam; Yani Sodiqah; Lisa Yuniati
KOLONI Vol. 5 No. 3 (2026): SEPTEMBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i3.1032

Abstract

Acne vulgaris is a common skin disease frequently associated with the colonization of Cutibacterium acnes and Staphylococcus epidermidis bacteria; however, repeated use of antibiotics risks triggering resistance, necessitating effective and safe natural alternatives. This study presents a literature review with a narrative review design on the potential of mangosteen peel (Garcinia mangostana L.) as an anti-acne antibacterial agent by analyzing 10 articles from PubMed, NCBI, and Google Scholar (2017–2025) that met the inclusion criteria. The results demonstrated that mangosteen peel extract possesses antibacterial activity against C. acnes and S. epidermidis, as evidenced by the formation of inhibition zones along with supportive Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values. The key compound $\alpha$-mangostin from the xanthone group plays a dominant role through the disruption of bacterial cell membranes and the inhibition of microbial metabolism, with flavonoids and tannins contributing synergistically. Furthermore, the antibacterial effectiveness is influenced by the extraction method, solvent type, and extract concentration, with a tendency for nonpolar–semipolar solvents to yield higher activity. Overall, these findings confirm the potential of mangosteen peel as a natural candidate for acne vulgaris therapy, although extract standardization, determination of optimal dosage, toxicity testing, and controlled clinical trials are still required to ensure safety, efficacy, and reproducibility in clinical applications.
Potential of Soursop Leaf Extract (Annona Muricata L.) as an Antimicrobial Against Staphylococcus epidermidis Aqil Fauziy; Nurelly N. Waspodo; Andi Alamanda Irwan; Yani Sodiqah; Dhian Karina; Muhammad Wirawan Harahap
International Journal of Health Science and Technology Vol. 7 No. 1 (2025): July
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/ijhst.v7i1.3966

Abstract

Staphylococcus epidermidis is an opportunistic bacterium that can cause infections, particularly in individuals with weakened immune systems. The increasing resistance to antibiotics has encouraged the use of medicinal plants such as soursop leaves (Annona muricata L.), which contain antibacterial compounds. This study aims to evaluate the antibacterial effectiveness of soursop leaf extract against the growth of Staphylococcus epidermidis at concentrations of 50%, 75%, and 100%. The study specifically investigated the inhibition zones formed at each concentration (50%, 75%, and 100%) of Annona muricata L. extract against Staphylococcus epidermidis, and compared the antibacterial activity across these three concentrations. This research used a laboratory experimental design with the Kirby-Bauer disc diffusion method to assess the antibacterial activity. The extract was prepared using 96% ethanol and tested at the concentrations stated. Gentamicin 10 μg was used as a positive control, while sterile distilled water served as the negative control. The inhibition zones were observed after 24 hours of incubation at 37°C. The results showed that soursop leaf extract at 50% and 75% concentrations produced inhibition zones categorized as resistant. At 100% concentration, the inhibition zone ranges from resistant to intermediate. The comparison across all three concentrations indicates that the 100% concentration demonstrated notable antimicrobial activity against Staphylococcus epidermidis.
Co-Authors Andi Alamanda Irwan Aqil Fauziy Dhian Karina Dian Amelia Abdi Lisa Yuniati Muhammad Wirawan Harahap Nurelly N. Waspodo Waode Afiqah Muyyasarah Nur Bahrani Zulfiyah Surdam