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All Journal JURNAL KIMIA SAINS DAN APLIKASI
Nur Azis
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Gadjah Mada University, Sleman|Gadjah Mada University|Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering

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Formulation and Synthesis of Vanillin from Clove Oil as a Chemosensor for Urea Detection in Urine Adyatma Bhagaskara; Mefi Nur Fadzila; Gavriel Hagai Paulus Sumlang; Sabrina Gita Pramesti; Nur Azis; Jumina Jumina
Jurnal Kimia Sains dan Aplikasi Vol 27, No 2 (2024): Volume 27 Issue 2 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.2.72-82

Abstract

Urea levels in urine play an important parameter in diagnosing bodily conditions through liver and kidney examinations. The typical reagent for detecting urea content in urine is para-dimethylaminobenzaldehyde (pDMAB). However, it has a drawback related to the instability of color in the resulting Schiff base compound (pDMAB-urea). In this study, the synthesized vanillin compound derived from clove oil serves as the foundational material for a urea chemosensor based on the colorimetric concept. The synthesized vanillin was characterized using FTIR, GC-MS, and 1H-NMR. The formulation of the vanillin compound as a sensor was conducted by assessing the suitable solvent, determining the optimal mass of vanillin, and evaluating the acid-base conditions of the sensor formulation system both qualitatively and quantitatively. Subsequently, the most effective formulation was selected for detecting urea in urine samples. The synthesis of vanillin yielded a purity level of 95%. The optimal formulation was obtained at an optimum mass of vanilla of 0.75 g in 50 mL of 96% ethanol and 10 mL of 10% NaOH. The color change in the sample was from colorless to greenish yellow (436 nm). The vanillin obtained was applied to urine samples with the best results at a sample dilution level of 10,000×.
Co-Authors Adyatma Bhagaskara Gavriel Hagai Paulus Sumlang Jumina Jumina Mefi Nur Fadzila Sabrina Gita Pramesti