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All Journal Indonesian Journal of Human Nutrition Midwinerslion : Jurnal Kesehatan STIKes Buleleng International Journal of Health and Pharmaceutical (IJHP) Jurnal Pharmactive Jurnal Edukasi Citra Olahraga
I Gede Agus Sindhu Aditama
Institut Teknologi Dan Kesehatan Bintang Persada
Humanities Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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EFEKTIVITAS DAN KEAMANAN KOMBINASI IVERMECTIN-DIETHYLCARBAMAZINE-ALBENDAZOLE VERSUS DIETHYLCARBAMAZINE-ALBENDAZOLE ATAU ALBENDAZOLE-IVERMECTIN PADA KASUS FILARIASIS: SUATU KAJIAN CAKUPAN Sindhu Aditama, I Gede Agus; Oviani, Gusti Ayu
MIDWINERSLION Jurnal Kesehatan STIKes Buleleng Vol. 9 No. 1 (2024): MIDWINERSLION Jurnal Kesehatan STIKes Buleleng
Publisher : LPPM STIKes Buleleng

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52073/mjksb.v9i1.432

Abstract

Filariasis merupakan penyakit yang banyak dijumpai di negara tropis disebabkan oleh infeksi Wuchereria bancrofti, Brugia malayi, dan Brugia timori melalui vektor nyamuk dari genus Culex, Anopheles, dan Aedes sp. yang membawa mikrofilaria. WHO menerapkan strategi Mass Drug Administration dengan menyarankan penggunaan antiparasit seperti ivermectin, diethylcarbamazine, dan albendazole untuk pengobatan filariasis. Saat ini, pelaksanaan penelitian mengenai efektivitas dan keamanan kombinasi tiga obat ivermectin-diethylcarbamazine-albendazole [IDA] hanya melibatkan sedikit negara. Kajian ini bertujuan untuk memetakan sejauh mana bukti yang mendukung efektivitas dan keamanan penggunaan kombinasi tiga terapi Ivermectin-Diethylcarbamazine-Albendazole [IDA] dibandingkan kombinasi dua terapi Diethylcarbamazine-Albendazole [DA] atau Ivermectin-Albendazole [IA] pada subjek dengan filariasis. Suatu kajian cakupan (scoping review) dilakukan dan dilaporkan berdasarkan panduan dari PRISMA dengan pencarian artikel pada database PubMed dan ScienceDirect dengan sejumlah 8 artikel memenuhi kriteria kelayakan. Sejumlah 6 dari 8 artikel terpilih menunjukkan kombinasi IDA lebih efektif untuk terapi filariasis dibandingkan kombinasi DA atau IA, namun berdasarkan keamanan terapi dilihat dari adanya efek yang tidak dikehendaki (adverse effects/AEs) lebih sering terjadi pada kelompok IDA daripada DA atau IA. AEs yang sering terjadi berada pada tingkat ringan sampai sedang seperti kelelahan, sakit kepala, arthralgia, mual, muntah, dan nyeri abdominal. Kesimpulan kajian cakupan ini adalah kombinasi terapi IDA lebih efektif dalam pembersihan mikrofilaremia maupun perubahan negatif nilai circulating filarial antigen (CFA) dibandingkan DA atau IA. Berdasarkan keamanan terapi, pemberian IDA dapat ditolerensi dengan baik oleh subjek. AEs lebih sering terjadi pada kelompok IDA dengan jenis AEs ringan hingga sedang.
EVALUASI PEMBERIAN TERAPI NSAID PADA PASIEN OSTEOARTHRITIS DI POLI RAWAT JALAN RS WISMA PRASHANTI Indra Marangyana, I Gede Bagus; Sindhu Aditama, I Gede Agus; Widiani, Ni Putu Astuti
Journal Pharmactive Vol. 3 No. 2 (2024): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64036/pharmactive.v3i2.58

Abstract

The prevalence of osteoarthritis in Indonesia has reached quite high numbers¾5% at the age of 40 years, 30% at the age of 40-60 years, and 65% of elderly people over 61 years. Osteoarthritis occurs more often in women than men. Osteoarthritis management is recommended in certain conditions using Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). NSAIDs have various side effects such as obstruction, impaired kidney function, cardiovascular disorders, gastrointestinal disorders. Therefore, it is necessary to evaluate the use of NSAIDs regarding appropriate indications, drug selection and dosage. This study aims to determine the profile of use and evaluate the rationality of NSAID prescribing. This type of research is descriptive observational. Data collection was carried out retrospectively using medical records at Wisma Prasanthi Hospital. The subjects of this study were outpatients in the period July-December 2023 and met the inclusion criteria. The results of the study showed that the highest use of NSAIDs was the non-selective group (100%), i.e. Diclofenac Sodium (48.71%), Meloxicam (23.07%), Ibuprofen (19.23%), Caltrofen (7.69%), and Topical NSAID is Diclofenac gel (1.28%). The rationality of prescribing oral and topical NSAIDs is 100% right indication, 100% right drug selection, and 100% right dose. The conclusion from this study is that the highest use of NSAIDs is the non-selective NSAID group and the rationality for correct indications, correct drug selection and correct dosage is 100%.
Effects of Smoking Habits on Omega-3 Food Intake in Adults Lorensia, Amelia; Aditama, I Gede Agus Sindhu; Suryadinata, Rivan Virlando; Raharjo, Dian Natasya
Indonesian Journal of Human Nutrition Vol. 10 No. 2 (2023)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2023.010.02.6

Abstract

Smoking habits have been shown to impact omega-3 food intake, and cigarette smoke can increase lipid peroxidation through the induction of oxidative stress.  Omega-3, an essential fatty acid, can be obtained through the consumption of fish, milk, eggs, and supplements. This cross-sectional research aimed to assess the relationship between omega-3 food intake and smoking habits. The research was conducted from March to June 2022 in Rungkut District, Surabaya, Indonesia. Data collected included the respondents’ quantities and frequency of consuming foods containing omega-3, namely fish, milk, and eggs. Additionally, the level of nicotine dependence among smokers was evaluated using the Fagerstrom Test for Nicotine Dependence (FTND). The method for data analysis was the chi-square test. The total respondents in this study were 116 people, consisting of 41 smokers and 75 non-smokers. No significant differences were observed in the consumption patterns of omega-3-rich foods, including eggs, fish, and milk, between smokers and non-smokers (p > 0.01 for each food item). However, a significant difference was observed in the consumption of supplements containing omega-3 between the smoker and non-smoker groups (p < 0.005). However, the overall omega-3 intake did not exhibit a significant difference between smokers and non-smokers. Notably, a higher proportion of respondents who smoked reported consuming omega-3 supplements compared to the non-smoker group. Consequently, there is a need to conduct further research to identify the underlying factors that influence the habit of smokers toward consuming omega-3.
Optimization of Nanogel Formulation of Piper Nigrum And Erythrina Subumbrans Extract As Anti-Inflammatory Based On Lontar Usadha Tiwang: Effectiveness Test On Mus Musculus Sindhu Aditama, I Gede Agus; Ayu Ratih Listiani, Putu
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025 ( Indonesia - Thailand)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.454

Abstract

Public health in Bali has long been supported by traditional medicine based on local wisdom, one of which is usadha tiwang. In practice, usadha tiwang uses black pepper (Piper nigrum) and dadap leaves (Erythrina subumbrans) to treat mokan disease, which is characterized by swelling and pain, typical symptoms of inflammation. Scientifically, both have been proven to have anti-inflammatory activity in both extract and cream preparations, although their use in topical nanogel formulations has not been explored. This study aims to conduct phytochemical screening, develop a combination nanogel formulation of P. nigrum and E. subumbrans extracts, and evaluate anti-inflammatory activity in vivo. Extraction was performed by maceration, using 96% ethanol (1:5) for P. nigrum and 70% ethanol (1:5) for E. subumbrans. A total of six nanogel formulas were prepared with varying gel base concentrations. Activity testing was performed on mice (Mus musculus) with 1% carrageenan induction on the paw, divided into eight groups (F1–F6, negative control, and positive control). Edema evaluation was performed using a plethysmometer, and the data were analyzed using the Kruskal-Wallis test. Screening results showed that P. nigrum ethanol extract contained alkaloids, flavonoids, and steroids, while E. subumbrans extract contained alkaloids, flavonoids, saponins, and steroids. All formulations had transmittance values ​​>90%. Statistical analysis showed a significant difference between treatment groups (p=0.002). The positive control (Voltaren® Emulgel) differed significantly from all test groups (p=0.000). Of the six formulas, F3 showed the most optimal effect with an inflammation inhibition percentage of 100% at the 60th minute of observation.
PENGARUH PEMBERIAN ELEKTROLIT BUAH NANAS TERHADAP DENYUT NADI SISWA SMK SAAT MELAKUKAN OLAHRAGA Nugraha, Iwan Saka; Udayani, Ni Wayan; Aditama, I Gede Agus Sindhu
Jurnal Edukasi Citra Olahraga Vol. 5 No. 1 (2025): Jurnal Edukasi Citra Olahraga
Publisher : STKIP Citra Bakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38048/jor.v5i1.4796

Abstract

Penelitian ini bertujuan mengetahui pengaruh minuman isotonik buah nanas terhadap efektifitas denyut nadi siswa SMK di Denpasar. Penelitian ini merupakan penelitian eksperimental menggunakan randomized pretest – posttest control group design dengan satu kelompok kontrol. Kelompok kontrol mengkonsumsi air mineral, sedangkan kelompok perlakuan mengkonsumsi minuman isotonik buah nanas. Setelah itu, atlet diukur intensitas denyut nadinya, sebanyak 3 kali, masing selama 1 menit. Pengukuran denyut nadi dilakukan sebelum latihan, sesaat latihan selama 60-90 menit dan setelah jeda istirahat 10 menit dari selesai latihan. Analisis data dengan menggunakan uji man-whitney. Hasil pengukuran denyut nasi pemberian minuman isotonic buah nanas terhadap denyut nadi siswa SMK baik sebelum olahraga, sesaat setelah olahraga, dan jedah 10 menit setelah latihan (p>0,05). Kesimpulan penelitian ini adalah konsumsi minuman isotonik tidak terlihat meningkatkan efektifitas denyut nadi atlet.
Co-Authors Amelia Lorensia Ayu Ratih Listiani, Putu Indra Marangyana, I Gede Bagus Nugraha, Iwan Saka Oviani, Gusti Ayu Raharjo, Dian Natasya Suryadinata, Rivan Virlando Udayani, Ni Wayan Widiani, Ni Putu Astuti