Sylvia
Faculty of Medicine, North Sumatera University, Medan, Indonesia

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The Effectiveness And Safety Of Oral Microbial Agents As An Adjunct Therapy For Atopic Dermatitis: A Systematic Review Sylvia; Daniel
The International Journal of Medical Science and Health Research Vol. 1 No. 3 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

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Background: Eczema, also known as atopic dermatitis (AD), is a chronic inflammatory skin condition that significantly impacts the quality of life for both children and adults, affecting up to 20% of children and 10% of adults globally. While topical corticosteroids (TCS) have been the primary treatment, their long-term use can lead to adverse side effects and corticophobia, underscoring the need for alternative therapies like microbial agents (MA) which have shown promise in improving eczema symptoms and reducing reliance on TCS.      Methods: This systematic review focused on full-text English literature published between 2014 and 2024 using the PRISMA 2020 guidelines. The literature was compiled using PubMed, ScienceDirect, and SagePub, among other online venues. Result: Five publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Conclusion: This systematic review suggests that microbial agents (MA) are a promising add-on therapy for moderate to severe eczema in children when used alongside topical corticosteroids (TCS). Mixed-strain probiotics and synbiotics showed the most significant improvement in eczema severity, but the optimal dosage and steroid-sparing effect require further investigation. Future research should explore MA's effectiveness across different age groups and severities of eczema.
Understanding the Incidence of T2DM Following Gestational Diabetes Mellitus: A Comprehensive Systematic Review Lydia Yusuf; Sylvia
The Indonesian Journal of General Medicine Vol. 1 No. 2 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

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Background: Gestational Diabetes Mellitus (GDM) is a common metabolic issue in pregnancy, marked by high plasma glucose levels first detected during pregnancy. Research shows that women with GDM have at least a seven-fold higher risk of developing T2DM compared to those with normal pregnancies.  This study aims to serve a comprehensive systematic review to analyze the incidence rate of T2DM after GDM in literatures of the last 10 years.  Methods: The review adhered to PRISMA 2020 standards and analyzed full-text English literature from 2014 to 2024. It excluded editorials, review papers from the same journal, and submissions lacking a DOI. Literature sources included PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of  500 articles were retrieved from online databases (PubMed, SagePub, SpringerLink and Google Scholar). After three rounds of screening, ten articles directly relevant to the systematic review were selected for full-text reading and analysis. Conclusion: Postpartum care and long-term monitoring for women with gestational diabetes mellitus (GDM) are essential due to the increased risk of type 2 diabetes mellitus (T2DM). Future research should target modifiable risk factors and enhance postpartum screening to mitigate associated health risks.