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All Journal Scientia Psychiatrica Journal of General Procedural Dermatology and Venereology Indonesia
Rahmadini, Meirina
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Health Professions Medicine & Pharmacology Neuroscience Public Health

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Efficiency of 7-dehydrocholesterol vitamin-D3 complex cream for xerosis and pruritus in elderly women Yahya, Yulia Farida; Rahmadini, Meirina; Jatmiko, Pandu Haryo; Emirzon, M. Afif Baskara; Nabila, Dewa Ayu Bulan; Kurniawati, Yuli; Toruan, Theresia Lumban; Riviati, Nur
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Xerosis and pruritus (XP) are the most common skin conditions in the elderly, manifesting clinically as roughness, scales, fissures, and mild-to-severe itching. Vitamin D improves skin hydration, transepidermal water loss (TEWL), and regulates the immune system. We aimed to determine the efficiency of topical 7-dehydrocholesterol (DHC)-vitamin D3 complex cream in elderly patients with XP. Methods: An experimental phase III study was performed on elderly women with XP from December 2021 to March 2022 at the Geriatric Dermatology Clinic of Dr. Mohammad Hoesin General Hospital, Palembang. Inclusion criteria were age older than 55 years, healthy or with comorbidity. The exclusion criteria include the use of moisturizer within two weeks before the study. DHC-vitamin D3 cream was applied on subject’s volar arms once a day. Overall dry skin score (ODSS), visual analog scale (VAS) for pruritus and adverse effects, skin hydration, TEWL, sebum level, serum vitamin D level, and dermatology life quality index (DLQI) were assessed at baseline and after 4 weeks. Statistical analysis was done with Wilcoxon and paired T-test. Results:Eighteen elderly women were included. Most subjects were 60 to 74 years old (83,3%). Half the subjects (50%) had comorbidity. There was a significant difference in skin hydration (p Conclusion: Topical 7-DHC vitamin D3 complex cream is proven to improve skin barriers, increase serum vitamin D levels, well-tolerated, and provided satisfaction and comfort in elderly women with XP.
Psychiatric Aspects of Lichen Simplex Chronicus: A Systematic Literature Review Rahmadini, Meirina
Scientia Psychiatrica Vol. 4 No. 3 (2023): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v4i3.121

Abstract

Introduction: Lichen simplex chronicus (LSC) is an eczematous skin condition characterized by thickened and 'lichenified' skin plaques. The involvement of psychological variables and transitory alleviation of pruritus following vigorous scratching appears to be critical in the development and maintenance of its course. Methods: The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding risk factors and clinical overview of acute kidney injury. The search was performed using the terms: (1) " psychiatric factors" OR "psychological factors" OR "stress" AND (2) "lichen simplex chronicus". Results: Studies and literature have described the relationship between skin lesions exacerbation and the level of psychopathological conditions in response to stress. Pruritus or itch is the most prominent symptom of LSC, which seems to have a marked psychological component. Conclusion: Psychiatric factors have a role in both the onset and persistence of this form of neurodermatitis.
Co-Authors Emirzon, M. Afif Baskara Jatmiko, Pandu Haryo Nabila, Dewa Ayu Bulan Nur Riviati, Nur Toruan, Theresia Lumban Yuli Kurniawati, Yuli Yulia Farida Yahya