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All Journal Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Astalitha Lorel Tania
Aisyiyah Hospital Bojonegoro
Health Professions Medicine & Pharmacology

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Acute kidney injury induced by beta-lactam antibiotics in children: A scoping review Astalitha Lorel Tania; Alya Ayu Tazkia
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.20376

Abstract

Antibiotics are the agents that cause Acute Kidney Injuries (AKI) in children. A recent study has shown the incidence of nephrotoxicity by antibiotics reaches 16% in children. Beta-lactam types are not widely known for their nephrotoxic effect. This study aims to examine beta-lactam antibiotics' role in inducing children's renal failure. This search for a scoping review on the effect of beta-lactam antibiotics in children was carried out in December-January 2022-2023. We used some search engines with the year of publication 2012-2022 then extracted. The keyword combinations used are: “beta-lactams” OR “β-lactams” AND “acute renal failure” OR “acute renal injury” OR “nephrotoxic” OR “nephrotoxicity” AND “children” OR “pediatric” OR “neonate” NOT “adult”. Studies were excluded if the: (i) adult; (ii) were a review, systematic review, or meta-analysis; (iii) written in a language other than English; (iv) not available in full text; (v) have kidney disease before (vi) in vitro or in vivo. The article selection process was based on PRISMA-ScR. From 4032 articles that met the search criteria, 3 studies met the inclusion criteria. The result shows that beta-lactam increases the risk of acute renal injury in children. This review emphasizes the importance of choosing kidney-safe antibiotics for children.
Diagnosing neglected pertussis in two pediatric case reports during the covid era: how is the prognosis Astalitha Lorel Tania; Retno Nurhayati
Paediatrica Indonesiana Vol. 66 No. 3 (2026): May 2026
Publisher : Indonesian Pediatric Society

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Abstract

Pertussis, caused by Bordetella pertussis, is a re-emerging and highly contagious respiratory infection that causes whooping cough in infants and older children. During the COVID-19 pandemic, diagnosis of pertussis has become more challenging because its respiratory manifestations often overlap with those of COVID-19. We report two cases of pertussis in children of different ages admitted to the pediatric ward of Aisyiyah Bojonegoro Hospital during the COVID-19 pandemic. The first case involved a 4-years-9 month-old boy who presented with persistent cough accompanied by a characteristic whooping sound for five days. The second case involved a 5-month-29-day-old girl who had experienced cough and low-grade fever for 21 days, marking her second episode of similar symptoms. Both patients were diagnosed with pertussis. These cases aim to describe and compare the clinical manifestations and outcomes of pertussis in children of different age groups. They also highlight the diagnostic challenges of pertussis during the COVID-19 pandemic in a region where pertussis remains a re-emerging disease. Pertussis in children may be underdiagnosed and underreported. Therefore, clinicians should consider pertussis in the differential diagnosis of children presenting with prolonged cough.
Co-Authors Alya Ayu Tazkia Retno Nurhayati