Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal AcTion: Aceh Nutrition Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan
Budiyanti Wiboworini
Department of Nutrition, Faculty of Medicine, Universitas Sebelas Maret
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The effect of EKORMIN on rats with diabetes mellitus model: effectiveness on fasting blood glucose, MDA, and insulin levels Siti Nurjana Kurniaty Tanaiyo; Budiyanti Wiboworini; Setyo Sri Rahardjo
AcTion: Aceh Nutrition Journal Vol 9, No 1 (2024): March
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v9i1.1312

Abstract

Antioxidant use for additional diabetes mellitus therapy is growing, such as  okra (Abelmoschus esculentus) and turmeric (Curcuma longa), which are rich in flavonoids and have beneficial effects on diabetes mellitus. This study aimed to determine the effects of okra turmeric extract (EKORMIN) on Fasting Blood Glucose (FBG), malondialdehyde (MDA), and insulin levels in diabetic rats. The research was conducted from December to January 2022 at PSPG UGM using experimental research with a pre-posttest-controlled group design. White male Wistar rats (n = 35) randomly grouped into five: negative control (STZ-NA), positive control (STZ-NA+metformin 1,8 mg/200 gBW), P1 (STZ-NA+EKORMIN low dose 130,5;110,5 mg/kgBW), P2 (STZ-NA+EKORMIN moderate dose 261;221 mg/kgBW), P3 (STZ-NA+EKORMIN high dose 522;442 mg/kgBW). The intervention lasted 14 days. Data analysis was performed using one-way analysis of variance statistical tests and post hoc follow-up tests. EKORMIN in all doses, EKORMIN reduced FBG and MDA levels and increased insulin levels (p<0,05). P2 and P3 were not significantly different from the metformin (PG) group (p>0,05). The decrease in FBG (-167,05±-2,8 vs -175,86±-1,4 mg/dL) and MDA levels (-6,32±0,33 vs -7,98±0,07 nmol/ml) P3 was higher than P2. Similarly for increased insulin levels (121,47±3,03 and 164,09±4,48 pg/ml). EKORMIN was effective in reducing FBG and MDA levels and increased insulin levels in diabetic rats. EKORMIN has antidiabetic effects and has potential for type 2 diabetes mellitus treatment.
Red Cabbage Juice Decreases Oxidative Stress in Hyperuricemia Model Rats Muhammad Abdul Rauf; Budiyanti Wiboworini; Paramasari Dirgahayu
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (714.06 KB) | DOI: 10.30604/jika.v8i2.1750

Abstract

Serum uric acid levels are recognized to be a substantial risk factor for developing oxidative stress-related illnesses. Red cabbage has the largest concentration of anthocyanins of any antioxidant, which contributes to oxidative stress. This study aimed to see how anthocyanins in red cabbage juice affected MDA levels in hyperuricemia model rats at different dosages and times of the intervention. A Randomized Complete Design was used to create a before and post-test group research design with 24 male Sprague-Dawley rats aged 10-12 weeks classified into four groups, the Control Group (KN) and the Treatment Group  (P1-3). KN rats received standard feed, whereas P1-3 received a regular meal and dosages of red cabbage juice of 1.8, 3.6, and 7.2 ml/200g BW for 28 days. Uric acid levels are measured before and after induction, whereas MDA levels are measured before the installation, after induction (Day 0), on Day 14, and on Day 28. Data analysis was performed utilizing the One Way Anova test, Repeated Measured ANOVA, and a mixed design. Statistical testing revealed that dosage and intervention duration differences significantly lowered MDA levels in all treatment groups (p less than 0.05). On day 28, the red cabbage juice intake of 7.2 ml/200grBB returned MDA levels to normal. Abstrak: Peningkatan asam urat serum diketahui menjadi risiko utama terkait perkembangan penyakit akibat stres- oksidatif. Kubis merah mengandung antosianin paling tinggi diantara jenis antioksidan lain yang berperan terhadap keadaan oksidatif stress.  Tujuan penelitian ini untuk mengetahui pengaruh antosianin dari jus kubis merah dengan variasi dosis dan lama waktu intervensi terhadap penurunan kadar MDA tikus model hiperurisemia. Penelitian Pre and post-test group esign dengan Rancangan Acak Lengkap menggunakan 24 tikus jantan Sprague-Dawley umur 10-12 minggu dibagi menjadi 4 kelompok yaitu Kelompok kontrol (KN) dan Kelompok Perlakuan (P1- 3). Tikus KN diberi pakan standart sedangkan P1-3 diberi pakan standart ditambah jus kubis merah dosis 1.8, 3.6, 7.2 ml/200g BB selama 28 hari. kadar asam urat dipantau sebelum dan setelah induksi, untuk kadar MDA dipantau sebelum Induksi, setelah induksi per Hari ke0, Hari ke 14 dan Hari Ke 28. Data dianalisi menggunakan uji One Way ANOVA, Repeated measured ANOVA dan mix design. Hasil uji statistik menjelaskan variasi dosis dan lama waktu intervensi terbukti nyata menurunkan kadar MDA pada semua kelompok perakuan (p kurang dari 0,05). Kesimpulannya jus kubis merah dosis 7,2 ml/200grBB mampu menurunkan kadar MDA mencapai batas normal pada hari ke 28.
Co-Authors Muhammad Abdul Rauf Paramasari Dirgahayu Setyo Sri Rahardjo Siti Nurjana Kurniaty Tanaiyo