Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal JURNAL PROMOSI KESEHATAN INDONESIA Journal of Biomedicine and Translational Research
Dwi Pudjonarko
Department of Neurology, Faculty of Medicine, Universitas Diponegoro
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Prevention Program for People Living with Stroke in Low and Middle-Income Country: A Systematic Review Aisyah Lahdji; Dwi Pudjonarko; Zahroh Shaluhiyah
Jurnal Promosi Kesehatan Indonesia Volume 19 No.2 Agustus 2024
Publisher : Master Program of Health Promotion Faculty of Public Health Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpki.19.2.93-100

Abstract

Background: Non-communicable diseases (NCDs) are the primary factors responsible for mortality and impairment on a global scale. By 2030, it is estimated that non-communicable diseases will comprise 80% of the global population. According to the World Health Organization (WHO), the risk of stroke will grow by 50% for the entire global population by 2022. Currently, it is projected that 1 in 4 individuals will suffer from a strokeMethod: This review was reported using the “Preferred Reporting Items for Systematic Reviews and Meta-Analysis” guideline and written using the “Synthesis without Meta-Analysis” method. The included studies for this review followed several criteria, including randomized controlled trials (RCT), English and Bahasa articles, using population was people living with stroke, intervention was any prevention and disability limitation, and outcomes were prevention measurements (primary, secondary, and tertiary prevention).Results: The study yielded multiple efficacious and streamlined preventive interventions implemented for stroke patients. Emphasizing risk factors as the main strategy for preventing health issues, using pharmacological treatments such as polypill, aspirin, and vitamins as a supplementary measure under the guidance of medical physicians and cardiologists. In addition, tertiary preventive initiatives encompass more than just administering drug treatment; they also require adherence to pharmaceutical protocols
The Role of Vitamin D3 in Preventing Ethambutol-induced Toxic Optic Neuropathy on Wistar Rat Model: A Pilot Study Riski Prihatningtias; Trilaksana Nugroho; Suharyo Hadisaputro; Dwi Pudjonarko
Journal of Biomedicine and Translational Research Vol 12, No 2 (2026): August 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i2.29962

Abstract

Background: Ethambutol toxic optic neuropathy (ETON) is one of the side effects of ethambutol (EMB) therapy in tuberculosis (TB) patients which can cause visual impairment. Prevention of this neurotoxicity is effective strategy to address this condition. Vitamin D3 has the potential to prevent ETON since vitamin D3 is a neuroprotective agent.Objective: To observe the effect of vitamin D3 in ETON wistar rat model through its effect on the excitotoxicity pathway.Methods: This study used a true experimental, post-test-only randomized controlled design. Fourteen Wistar rats were randomly divided into two groups. All rats received EMB at a dose of 32 mg per 200 g body weight per day for 30 days. The treatment group also received oral vitamin D3 at 72 IU per 200 g body weight per day. NMDA receptor expression was examined using immunohistochemical (IHC) staining, and retinal ganglion cell (RGC) density was analyzed using Hematoxylin-Eosin (HE) staining. Differences in NMDA receptor expression were tested using the Mann–Whitney test, while RGC density was analyzed with an Independent T-test followed by Spearman’s correlation test.Results: The expression of NMDA receptors in the treatment group given vitamin D3 was lower than the control (62.00 ± 16.43 and 70.00 ± 7.07, respectively) with no statistically significant result (p=0.502). Retinal ganglion cell density in the treatment group was higher and statistically significant when compared with the control group (11.36 ± 0.51 and 9.60 ± 1.14, p=0.014). The results of the Spearman's correlation test between NMDA receptor expression and RGC density were found to be p=0.380.Conclusion: Oral vitamin D3 has an effect to increase RGCs density in rats given ethambutol.
Co-Authors Aisyah Lahdji Riski Prihatningtias Suharyo Hadisaputro Trilaksana Nugroho Zahroh Shaluhiyah