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All Journal Majalah Obat Tradisional
Arief Nurrochmad
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281
Health Professions Medicine & Pharmacology Public Health

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Immunostimulant Activities of Dioscorea esculenta L. Tubers Based on Phagocytic Activity and Lymphocyte Proliferation In Vitro Ika Puspitaningrum; Muthi' Ikawati; Nanang Fakhrudin; Arief Nurrochmad
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.98776

Abstract

The immune system plays an important role for the body, especially in protecting it from exposure to bacteria, viruses, and other foreign bodies. Improving the immune system can be done by daily consumption of certain foods. Foods that can be developed into an immunostimulant are tubers, one of which comes from the genus Dioscorea. Dioscorea esculenta L., known as gembili tuber, is widely found in Indonesia, but has not been widely tested for its activity as an immunostimulant both against the innate and adaptive immune systems. This study aims to determine the immunostimulant activity of aqueous extract (AE), polysaccharide fraction (PF), and non-polysaccharide fraction (NPF) of gembili tubers against macrophage phagocytosis activity and lymphocyte proliferation. Test of phagocytosis activity and lymphocyte proliferation was performed in vitro by adding AE, PF, NPF gembili tubers 12.5, 50, and 100 mg/mL, inulin 100 µg/mL, and positive control 10 mg/mL as a comparison in macrophage cells and mouse lymphocyte cells. Phagocytosis activity was expressed in phagocytosis capacity and phagocytosis index, while lymphocyte proliferative activity was expressed in proliferative stimulating index. The results showed that AE, PF, and NPF could increase macrophage phagocytosis activity, with the highest activity observed at AE 100 μg/ml, PF 100 μg/ml, and NPF 12.5 μg/ml. AE, PF, and NPF were also shown to increase lymphocyte proliferation activity, with the most significant enhancement observed at AE 12.5 μg/mL, PF 12.5, and NPF 50 μg/mL.
Antioxidant, Anti-Inflammatory, and Safety Assessments of Cengkodok Plant (M. malabathricum): A Narrative Review Pratiwi Apridamayanti; Arief Nurrochmad; Rumiyati Rumiyati; Abdul Rohman
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.111406

Abstract

This review aimed to provide a scientific and rational basis for developing the Melastoma malabathricum plant into an herbal medicine capable of providing effective, safe therapy for long-term use in diseases originating from oxidative stress processes and associated with inflammatory events, including diabetes, cardiovascular disorders, and neurodegenerative diseases. Electronic searches of the Scopus and Web of Science (WOS) databases identified relevant articles. The literature search and screening were conducted on March 2, 2025. Keywords such as (“Melastoma malabathricum”) AND (antioxidant* OR “anti-inflammatory” OR “anti-inflammatory” AND anti-inflammation* OR anti-inflammation) were used to obtain articles published between 2006 and 2024. During the process, only original, English-language studies reporting M. malabathricum anti-inflammatory or antioxidant properties were included, while reviews, conference abstracts, preprints, retracted, irrelevant, and duplicate papers were excluded. A total of 39 articles fulfilled the inclusion criteria and were subjected to critical evaluation. The results showed that M. malabatricum plant extract demonstrated consistent anti-inflammatory activity. Pathways of mechanisms and safety profiles were reported across in vitro and in vivo assays. In conclusion, this narrative review of the studies provides comprehensive, integrated information from the scientific literature on the antioxidant, anti-inflammatory, and safety activities of M. malabathricum plant extracts. The results offer a strong scientific foundation for the rational development of the plant extracts as an anti-inflammatory drug candidate.
Co-Authors Abdul Rohman Ika Puspitaningrum Muthi' Ikawati Nanang Fakhrudin Pratiwi Apridamayanti Rumiyati Rumiyati