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All Journal Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal
Nieka Adhara Wahono
Department Of Pediatric Dentistry, Faculty Of Dentistry, Universitas Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Dentistry Public Health

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Maternal Zinc Diet Impairs Learning and Memory in Offspring Rats through the CREB/BDNF Pathway Novi Dewi Tanjung; Nieka Adhara Wahono; Ninik Mudjihartini; Ani Retno Prijanti
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.3021

Abstract

BACKGROUND: Zinc released into the synaptic cleft able to modulate various signaling pathways, including brain derived neurotrophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB). Zinc binding to its receptor, G-protein coupled receptor 39 (GPR39), may trigger biochemical pathways leading to cAMP response element binding protein (CREB)-dependent gene transcription that subsequently promotes BDNF upregulation. Therefore, zinc dyshomeostasis should be considered as a condition that induces disruption of CREB/BDNF signaling. This study was conducted to examine the effect of maternal zinc diet on hippocampal expression levels of CREB and BDNF in offspring.METHODS: One-day pregnant rats were randomly divided into five groups: zinc-deficient (D), zinc-restricted (R), zinc-adequate (A), zinc-supplemented (S), and excess zinc-supplemented (ES). The groups had different zinc diets during pregnancy and lactation. The behavioral function of the offspring was tested with Y-maze at the 43th postnatal. Hippocampus was isolated, BDNF was assessed by quantitative real-time polymerase chain reaction (qRT-PCR), and CREB was examined using sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Spatial working memory measurement demonstrated that D and ES group exhibited a significantly lower spontaneous alternation than other groups. The qRT-PCR and ELISA analysis revealed the hippocampal expression level of BDNF and CREB decreased in groups D and ES, but tended to increase in groups R and S, until the highest expression peak was found in group A.CONCLUSION: High and low intake of zinc induces lower expression of BDNF and CREB in hippocampus, which further impairs learning and memory. Our findings suggest the signaling pathway of CREB/BDNF is involved in zinc dyshomeostasis-induced cognitive impairments.KEYWORDS: hippocampus, BDNF, CREB, TrkB, GPR39, zinc, diet, LTP
Early intervention of anterior crossbite and unfavorable tongue posture with a prefabricated myofunctional appliance: A case report Putri Ganesha Asturini; Nieka Adhara Wahono
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p415-420

Abstract

Background: Anterior crossbite in the primary dentition may be an early indicator of a developing Class III malocclusion. Clinical findings, hereditary factors, and environmental influences, such as breathing problems and tongue posture, should be considered for early intervention. Purpose: This case report describes the early diagnosis and intervention of anterior crossbite and unfavorable tongue posture as potential risk factors contributing to a Class III growth pattern. Case: An 8-year-old girl with a history of preterm birth and a familial history of Class III malocclusion presented with the chief complaint: lower teeth in front of upper teeth. Clinical findings included anterior crossbite in the primary canines, mild lower incisor crowding, and mesiocclusion in both second primary molars. The cephalogram revealed bimaxillary retrusion (SNA = 79°, SNB = 74°), a skeletal Class I (ANB = 4°, Wits = –2 mm), and a forward tongue posture. Case Management: An ENT specialist diagnosed the patient with allergic rhinitis, without any airway obstruction. A prefabricated myofunctional appliance was prescribed to guide the eruption of permanent teeth into their ideal positions, eliminate maxillary growth restriction, and retrain tongue posture. The anterior crossbite of the primary teeth and the crowding were corrected within 9 months. Use of the appliance is ongoing until all permanent incisors have fully erupted and ideal occlusion is achieved. Conclusion: Myofunctional therapy during early mixed dentition may serve as a beneficial interceptive treatment to retrain orofacial muscles and guide the eruption of permanent teeth into an ideal occlusion.
Co-Authors Ani Retno Prijanti Ninik Mudjihartini Novi Dewi Tanjung Putri Ganesha Asturini