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All Journal Asian Journal of Analitycal Chemistry
Nabila Ramadhani
Alma Ata University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

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ANALYSIS OF MEFENAMIC ACID LEVEL IN HERBAL MEDICINE FOR SCIATICA PAIN (AIR MANCUR) BY UV-VIS SPECTROPHOTOMETRIC METHOD Baiq Husnul Hotimah Septiandi; Eva Larassati; Nabila Ramadhani; Abd Sukri S Manusu
Asian Journal of Analytical Chemistry Vol. 1 No. 2 (2023): Asian Journal of Analytical Chemistry
Publisher : DAS Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53866/ajac.v1i2.410

Abstract

Herbal medicine is a traditional medicine that is still popular today among the public. Herbal medicine for pain and rheumatism is one type of herbal medicine that is in great demand by consumers. Herbs are often added with medicinal chemicals to provide a faster and more effective effect so that it can attract consumers to use these herbal products, but basically the use of medicinal chemicals in herbal medicine is a dangerous thing because the dose contained in the herbal medicine is unknown but still used for a long time. The method used is the UV-Vis spectrophotometric method with a wavelength range of 200-400 nm. The research began with the collection of herbal medicine samples taken randomly in one of the shops in the city of Yogyakarta, the samples used were herbal medicine for sciatica pain produced by air mancur, then wavelength readings were taken, mefenamic acid standard solution analysis, and method validation. The method validation results obtained are the correlation value (R2) of 0.9998, the LOD value of 0, 073343 and LOQ 0.244476 ppm. This value exceeds the LOD and LOQ values so that it can be interpreted that the herbal medicine sample has a mefamic acid content of 4.643 ppm or 1.266%.
DETERMINATION OF PARACETAMOL LEVELS USING THE UV-VIS SPECTROPHOTOMETRY METHOD Abd Sukri S Manusu; Nabila Ramadhani; Eva Larassati; Baiq Husnul Hotimah Septiandi
Asian Journal of Analytical Chemistry Vol. 1 No. 2 (2023): Asian Journal of Analytical Chemistry
Publisher : DAS Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53866/ajac.v1i2.413

Abstract

Paracetamol is analgesic and antipyretic Which introduced on treatment on year 1950s. Paracetamol reduces pain by inhibiting the cyclooxygenase enzyme and preventing the production of prostaglandins in the central and peripheral nervous system. Ultraviolet-visible (UV -Vis) is a technique used to analyze substances containing components that absorb in the visible ultraviolet region. The advantages of the UV-Vis method are that the analysis technique is fast, the equipment is easy to use, uses less solvent and reagents, and is more cost effective. The operating principle of a UV-Vis (Ultra Violet-Visible) spectrophotometer is based on light absorption, where atoms and molecules interact with light. The aim of this research is to develop or validate a fast, accurate and efficient analytical method for determining the concentration of paracetamol in various drugs or medicines, thus supporting monitoring of the quality, safety and effectiveness of these products in a product. clinic s. The validation results of this method show that this method is good for detecting mefenamic acid in herbal medicine with a correlation coefficient (r) of 0.9478 and (r2 ) of 0.9736; limit of detection (LOD) 13.42679 ppm; limit of quantification (LOQ) 44.75595. The herbal medicine samples contained paracetamol on average 5,487 ppm.
Co-Authors Abd Sukri S Manusu Baiq Husnul Hotimah Septiandi Eva Larassati