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Rika Hartati
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KARAKTERISASI DAN PENAPISAN FITOKIMIA SIMPLISIA WORTEL SERTA REVIEW KANDUNGAN KIMIA DAN AKTIVITAS FARMAKOLOGI WORTEL (DAUCUS CAROTA L.) Rika Hartati; Fidrianny, Irda; Fitria, Alfiyani
Acta Pharmaceutica Indonesia Vol. 48 No. 2
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i2.22428

Abstract

Carrot is an important source of nutrition for humans and a good source of dietary fiber. Carrot are rich in bioactive compounds such as phenolic compounds, carotenoids, polyacetylene, and ascorbic acid which has health effects. Carrot are known to have many health benefits such as antioxidants, antidiabetic, antiinflammatory, antihypertensive, antibacterial, and antifungal. This study aims to determine the characteristics and phytochemical screening of root, leaves and stem carrot (Daucus carota L) and prepare a review article about chemical compounds and pharmacological activities of carrot. Characterization performed of crude drug included macroscopic and microscopic, determination of total ash content, acid insoluble ash, water soluble ash, water content, water soluble extract, ethanol soluble extract, and loss on drying. Phytochemical screening was carried out to check the presence of secondary metabolite in crude drug. Root, leaves and stem of carrot extracted by reflux method with n-hexane, ethyl acetate, and 96% ethanol. Review article was prepared by considering and analyzing literatures. Water content of roots, leaves and stem of carrot were 5%, 4,17% and 6,67%, respectively. All crude drugs contained flavonoid, phenol, quinone and steroid/triterpenoid groups. Article review was done by collecting and analysing 82 literatures. The water of all crude drugs fulfilled the requirement. Wortel (Daucus carota L.) has many chemical compounds and pharmacological activities. Keywords: carrot, characterization, phytochemical screening, chemical compounds, pharmacological activities
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN SUBFRAKSI DAUN PEPAYA (CARICA PAPAYA L.) TERHADAP BAKTERI PENYEBAB JERAWAT Rika Hartati
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Propionibacterium acne and Staphylococcus epidermidis are the major bacteria that infect skin which can cause many disease in the skin, one of them is acne. Papaya is one of the plants that has many activities, such as antibacterial activity. In traditional use, papaya leaves used for treatment of acne. In this study, the antibacterial activity of n-hexane, ethyl acetate, and ethanol papaya leaves extract were tested against Propionibacterium acne and Staphylococcus epidermidis ATCC 12228 using agar diffusion disc method, microdilution method to determine minimum inhibitory concentration (MIC), and bioautography test. The preliminary result with diffusion disc showed that at 5% concentration of n-hexane extract of papaya leaves produced the largest inhibit zone for both bacteria, 7,43 mm for Propionibacterium acne and 7,78 mm for Staphylococcus epidermidis. The result showed that the MIC of n-hexane extract of papaya leaf were >4096 µg/mL. The result of the bioautography test of n-hexane extract showed the inhibition zone at Rf 0,09-0,28 and Rf 0,63 in chloroform-n-hexane system (6:3) for Propionibacterium acne. Based on the test result, the n-hexane extract of papaya leaves was continued to the fractination stage by chromatotron method and the compound at Rf 0,27 were selected as the target. The fraction was monitored by thin-layer chromatography (TLC) and the fraction contained the active compound was continued to subfractination stage by preparative chromatography method. The subfraction was tested against Propionibacterium acne and Staphylococcus epidermidis by bioautography method at 600 µg/mL concentration. It resulted an inhibitory zone at Rf 0,25-0,27 for Staphylococcus epidermidis and Rf 0,27 for Propionibacterium acne. Based on the result characterization of subfraction of n-hexane extract of papaya leaves by specific visualization reagent, the subfraction was predicted contain steroid/triterpenoid compound. Keywords: antibacterial, acne, papaya leaves, Carica papaya L., biootografi
Co-Authors Fitria, Alfiyani Irda Fidrianny