Hermawan Susanto
Division of Endocrinology and Metabolic Disease, Department of Internal Medicine, Faculty

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Approach to Refractory Hypoglycaemia in a Patient with Hepatocellular Carcinoma: A Case Study and Literature Review Audy Meutia Ariana; Ganjar Adityo Permadi; Hermawan Susanto
Journal of Agromedicine and Medical Sciences Vol 10 No 1 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i1.45924

Abstract

Symptomatic hypoglycaemia in patients without underlying diabetes is uncommon. Etiology of non-diabetic hypoglycaemia varies from hyperinsulinism, hormone deficiencies, malignancies, to critical illness. This case report illustrates the attempt to determine the cause of refractory hypoglycaemia in a 46 years old male patient with underlying hepatocellular carcinoma (HCC). Anamnesis and examinations have narrowed differential diagnosis to concurrent systemic illness (liver failure due to HCC) or paraneoplastic syndrome from non-beta cell tumors, referred as non-islet cell tumor hypoglycaemia (NICTH). It was noted that the absence of chronic liver disease stigmata has put NICTH as the possible main cause. Deciding what diagnostic modalities needed to perform to establish the diagnosis eventually relies on clinical judgement while taking cost-effectiveness and patients’ preference in consideration, particularly in low-resource settings. Nonetheless, the main goal of treating hypoglycaemia is to immediately achieve and sustain euglycemia which can be achieved conservatively or definitively with surgery despite the etiology. Keywords: Hepatocellular carcinoma, Hypoglycaemia, NICTH.