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All Journal Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Journal of Pharmaceutical and Sciences. Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Joni Tandi
Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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TOTAL FLAVONOID DAN EFEKTIVITAS EKSTRAK ETANOL BIJI KELOR (Moringa oleifera L) ASAL KOTA PALU SULAWESI TENGAH TERHADAP HISTOPATOLOGI PANKREAS TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI STREPTOZOTOCIN Viani Anggi; Joni Tandi; Veronika Veronika
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.294

Abstract

This study aims to determine the content of flavonoid and the effect of ethanol extract of moringa seeds on the regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes. This study method used has total flavonoid equivalent quercetin by spectrophotometry uv-vis and to regeneration of pancreatic β cells in male white rats used 30 test animals,namely male white rats divided into 6 groups, each group consisted of 5 male white rats with details of group I as normal control, Group II as negative control given 0.5% Na-CMC suspension, Group III as positive control given glibenclamide suspension and in Groups IV, V, and VI were given with each dose of 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BB. Histopathological damage picture of the pancreas was observed by staining HE using a 400x magnification olympus Cx21 microscope. The results showed that the ethanol extract of moringa seeds contained secondary metabolites, namely flavonoids, alkaloids, saponins and tannins. The results showed has total flavonoid equivalent quercetin of moringa seeds is 1,26% and regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes of Moringa seed ethanol extract at a dose of 400 mg/kg BB can have an effect on the regeneration of β cells in the pancreas of white diabetic male rats.
UJI POTENSI EKSTRAK DAUN BENALU BATU (BEGONIA SP) TERHADAP KADAR GLUKOSA DALAM DARAH DAN GAMBARAN HISTOPATOLOGI PANKREAS TIKUS PUTIH JANTAN (RATTUS NORVEGICUS) Joni Tandi; Dela Erni Paerunan; Nurifa Nurifa; Yunlis Silintowe Kenta; Sri Mulyani
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.384

Abstract

This study aims to determine the potential for glucose levels in the blood of ethanol extracts of the begonias (Begonia Sp.), the effect of the extract on the pancreatic histopathology of white rats (Rattus norvegicus) which was induced by streptozotocin, and the effective dose begonias’ extract leaves on the histopathological descriptions of pancreatic male white rats. This study was an experimental laboratory where the research group consisted of group I (the control group) as a normal control was given a standard feed, group II (negative control) was given a 0.5% Na CMC suspension, group III (positive control) was orally given glibenclamide and experimental groups IV, V, and VI (doses 50, 100, and 200 mg/kg BW). Were given ethanol extract of begonias leaves. The results showed that the ethanol extract of the begonias (Begonia Sp.) contained secondary metabolite compounds, namely flavonoids, alkaloids, saponins, polyphenols, and tannins. Ethanol extract of begonias leaves at adose of 50 mg/kg BW was an affective dose in reducing blood glucoselevels by an avarage of 101,8 mg/dL) and a dose of 50 mg/kg BW can affect the histopathological picture of the pancreas in STZ induuced rats with an average damage value of 2 from a maximum of 4.
Edukasi Jamu Dan Obat Herbal: Manfaat, Risiko, Dan Cara Penggunaan Yang Tepat Joni Tandi; Tien Wahyu Handayani; Mariyani Mariyani; Putri Adam Tandy
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 5 No. 6 (2025): November 2025 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59395/altifani.v5i6.882

Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan masyarakat tentang pemanfaatan jamu dan obat herbal sebagai alternatif pengobatan yang aman dan efektif. Kegiatan dilaksanakan pada hari Sabtu, 26 Juli 2025 di Jl. Emmy Saelan No.106, Kelurahan Tatura Utara, Kecamatan Palu Selatan, RT 01, RW 08 yang dihadiri oleh 43 warga masyarakat. Metode yang digunakan adalah participatory learning melalui ceramah, diskusi, dan tanya jawab. Hasil menunjukkan peningkatan pengetahuan masyarakat secara signifikan, dimana persentase peserta yang menjawab "Tidak Tahu" menurun dari 85% menjadi 3,33%, sementara yang menjawab "Tahu" meningkat dari 15% menjadi 96,67% setelah pemaparan materi. Kegiatan ini berhasil memberikan edukasi praktis tentang manfaat, risiko, dan cara penggunaan jamu dan obat herbal yang tepat.
Profil senyawa metabolit sekunder dari fraksi n-heksana dan etil asetat daun cengkeh (Syzygium aromaticum L.) menggunakan LC-HRMS Rezky Yanuarty; Siti Nurhaliza; Halik Alamsyah; Joni Tandi; Muthmainah Tuldjanah; Ayu Wulandari; Kevin Maengko; Recky Patala
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1138

Abstract

The diversity of plants available in nature, the majority have the potential as a source of traditional medicine due to the presence of secondary metabolites in various parts of the plant, especially the leaves. The object of the study was clove leaves (Syzygium aromaticum L.), a plant species abundant in secondary metabolites including alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids. This research aims to compare the profile of secondary metabolites in clove leaves (Syzygium aromaticum L.) in the n-hexane and ethyl acetate fractions. The research methodology includes phytochemical screening of secondary metabolites of the n-hexane and ethyl acetate fractions of clove leaves (Syzygium aromaticum L.) with dye reagents and LC-HRMS analysis. Phytochemical screening of the n-hexane fraction confirmed the presence of steroids, while the ethyl acetate fraction confirmed flavonoids, tannins, and steroids. The results of identification using the LC-HRMS instrument on the N-Hexane and Ethyl Acetate fractions of clove leaves (Syzygium aromaticum L) using LC-HRMS contained phenolic, flavonoid and phenylpropanoid compounds. In the results of the chromatogram in the N-Hexane fraction, Rhamnetin compound was obtained which had an area percent of 0.362% with the highest area of 10954249. Meanwhile, in the results of the ethyl acetate fraction chromatogram, eugenol compounds were obtained with an area percent of 0.37% with the highest area of 33151358.
Effect of Red Gedi Leaf Extract (Abelmoschus manihot) (L). Medik on Total Cholesterol of Hypercholesterolemia Diabetic Male Rat: Pengaruh Ekstrak Daun Gedi Merah (Abelmoschus manihot) (L). Medik) pada Kadar Kolesterol Total Tikus Putih Jantan Hiperkolesterolemia Diabetes Tien Wahyu Handayani; Monalisa Parinding Mallisa; Joni Tandi; Yuliet Yuliet
Journal Pharmasci (Journal of Pharmacy and Science) 2024: Journal Pharmasci (Journal of Pharmacy and Science) - Special Issue - The 18th Mulawarman Phar
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.vi.428

Abstract

Gedi Red Leaf is a plants that contains chemicals such as alkaloids, flavonoids, saponins, tannins and polyphenols. This study aims to prove the ability of ethanol extract of red gedi leaf (Abelmoschus manihot (L.) Medik) in lowering total cholesterol levels of the male white rat model of diabetes and hypercholesterolemia, dosing leaf extract of red gedi mostly effective in lowering total cholesterol levels in white rats male. Gedi red leaf extract made by maceration with 96%. The design of the study was a randomized block design (RBD). Data were analyzed using statistical tests one way (ANOVA) at the level of 95% used 42 male rats which were divided into six treatment groups, each treatment consisting of 7 animals. Group I as a negative control by suspense Na CMC 0.5%, group II as a control pain by Na-CMC suspension 0.5%, Group III as a positif control by the suspension of simvastatin 0.9 mg / kg BW, groups IV, V and VI were given ethanol extract of leaf of red gedi, each with a dose of 150 mg/ kg BW, 300 mg/ kg BW and 450 mg/ kg BW. All treatment groups were given high-cholesterol feed except fructose synthetic and negative groups. Based on Duncan test it shows that the dose of ethanol extract of leaf of red gedi effective is 450 mg / kg BW.
Profil senyawa metabolit sekunder dari fraksi n-heksana dan etil asetat daun cengkeh (Syzygium aromaticum L.) menggunakan LC-HRMS Rezky Yanuarty; Siti Nurhaliza; Halik Alamsyah; Joni Tandi; Muthmainah Tuldjanah; Ayu Wulandari; Kevin Maengko; Recky Patala
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1138

Abstract

The diversity of plants available in nature, the majority have the potential as a source of traditional medicine due to the presence of secondary metabolites in various parts of the plant, especially the leaves. The object of the study was clove leaves (Syzygium aromaticum L.), a plant species abundant in secondary metabolites including alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids. This research aims to compare the profile of secondary metabolites in clove leaves (Syzygium aromaticum L.) in the n-hexane and ethyl acetate fractions. The research methodology includes phytochemical screening of secondary metabolites of the n-hexane and ethyl acetate fractions of clove leaves (Syzygium aromaticum L.) with dye reagents and LC-HRMS analysis. Phytochemical screening of the n-hexane fraction confirmed the presence of steroids, while the ethyl acetate fraction confirmed flavonoids, tannins, and steroids. The results of identification using the LC-HRMS instrument on the N-Hexane and Ethyl Acetate fractions of clove leaves (Syzygium aromaticum L) using LC-HRMS contained phenolic, flavonoid and phenylpropanoid compounds. In the results of the chromatogram in the N-Hexane fraction, Rhamnetin compound was obtained which had an area percent of 0.362% with the highest area of 10954249. Meanwhile, in the results of the ethyl acetate fraction chromatogram, eugenol compounds were obtained with an area percent of 0.37% with the highest area of 33151358.
Co-Authors Ayu Wulandari Dela Erni Paerunan Halik Alamsyah Kevin Maengko Mariyani Monalisa Parinding Mallisa Muthmainah Tuldjanah Nurifa Nurifa Putri Adam Tandy Recky Patala Rezky Yanuarty Siti Nurhaliza Sri Mulyani Tien Wahyu Handayani Veronika Veronika Viani Anggi Yuliet Yuliet Yunlis Silintowe Kenta