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All Journal Jurnal Akademika Kimia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Joni Tandi
Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
Chemistry Education Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Determination of Secondary Metabolites and Antioxidant Activity of Robusta Coffee Bean Ethanol Extract by UV-Vis Spectrophotometry Joni Tandi; Ni P. I. Riani; Tien W. Handayani; Maria Kanan
Jurnal Akademika Kimia Vol. 12 No. 1 (2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2023.v12.i1.pp58-64

Abstract

Robusta coffee beans (Coffea canephora Pierre ex.A.Froehner) have antioxidant, antidiabetic, and antihypertensive effects and can prevent coronary heart disease. This study aims to determine the compound content and total levels of secondary metabolites and to determine the antioxidant activity of robusta coffee bean extract. UV-Vis spectrophotometer was used to determine the total levels of secondary metabolites and antioxidant assay using DPPH reagent. The results obtained for the positive qualitative test contain secondary metabolites of alkaloids, flavonoids, saponins, and tannins and do not contain steroid compounds while for the quantitative test, the total alkaloid content is 0.1973% w/w (caffeine equivalent), flavonoids are 1.2106% w/w (equivalent to quercetin), saponins 0.536% w/w (equivalent to sapogenins), tannins at 9.7103% w/w (equivalent to tannic acid). The IC50 result for the antioxidant activity of the ethanolic extract of robusta coffee beans is 55.16 µg/mL which is included in the category of strong antioxidants.
TOTAL FLAVONOID DAN EFEKTIVITAS EKSTRAK ETANOL BIJI KELOR (Moringa oleifera L) ASAL KOTA PALU SULAWESI TENGAH TERHADAP HISTOPATOLOGI PANKREAS TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI STREPTOZOTOCIN Viani Anggi; Joni Tandi; Veronika Veronika
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.294

Abstract

This study aims to determine the content of flavonoid and the effect of ethanol extract of moringa seeds on the regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes. This study method used has total flavonoid equivalent quercetin by spectrophotometry uv-vis and to regeneration of pancreatic β cells in male white rats used 30 test animals,namely male white rats divided into 6 groups, each group consisted of 5 male white rats with details of group I as normal control, Group II as negative control given 0.5% Na-CMC suspension, Group III as positive control given glibenclamide suspension and in Groups IV, V, and VI were given with each dose of 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BB. Histopathological damage picture of the pancreas was observed by staining HE using a 400x magnification olympus Cx21 microscope. The results showed that the ethanol extract of moringa seeds contained secondary metabolites, namely flavonoids, alkaloids, saponins and tannins. The results showed has total flavonoid equivalent quercetin of moringa seeds is 1,26% and regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes of Moringa seed ethanol extract at a dose of 400 mg/kg BB can have an effect on the regeneration of β cells in the pancreas of white diabetic male rats.
UJI POTENSI EKSTRAK DAUN BENALU BATU (BEGONIA SP) TERHADAP KADAR GLUKOSA DALAM DARAH DAN GAMBARAN HISTOPATOLOGI PANKREAS TIKUS PUTIH JANTAN (RATTUS NORVEGICUS) Joni Tandi; Dela Erni Paerunan; Nurifa Nurifa; Yunlis Silintowe Kenta; Sri Mulyani
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.384

Abstract

This study aims to determine the potential for glucose levels in the blood of ethanol extracts of the begonias (Begonia Sp.), the effect of the extract on the pancreatic histopathology of white rats (Rattus norvegicus) which was induced by streptozotocin, and the effective dose begonias’ extract leaves on the histopathological descriptions of pancreatic male white rats. This study was an experimental laboratory where the research group consisted of group I (the control group) as a normal control was given a standard feed, group II (negative control) was given a 0.5% Na CMC suspension, group III (positive control) was orally given glibenclamide and experimental groups IV, V, and VI (doses 50, 100, and 200 mg/kg BW). Were given ethanol extract of begonias leaves. The results showed that the ethanol extract of the begonias (Begonia Sp.) contained secondary metabolite compounds, namely flavonoids, alkaloids, saponins, polyphenols, and tannins. Ethanol extract of begonias leaves at adose of 50 mg/kg BW was an affective dose in reducing blood glucoselevels by an avarage of 101,8 mg/dL) and a dose of 50 mg/kg BW can affect the histopathological picture of the pancreas in STZ induuced rats with an average damage value of 2 from a maximum of 4.
Co-Authors Dela Erni Paerunan Maria Kanan Ni P. I. Riani Nurifa Nurifa Sri Mulyani Tien W. Handayani Veronika Veronika Viani Anggi Yunlis Silintowe Kenta