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All Journal Jurnal Sehat Indonesia (JUSINDO)
Rashida S Djatnika
RSUD Kabupaten Bekasi
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Vitamin D Supplementation Dose as The Prevention of Fragility Fracture In Chronic Kidney Disease Patient: A Systematic Review Aldico J Sapardan; Rashida S Djatnika
Jurnal Sehat Indonesia (JUSINDO) Vol. 6 No. 02 (2024): Jurnal Sehat Indonesia (JUSINDO)
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v6i02.118

Abstract

CKD affects more than 10% of the global population. It can cause osteoporosis and increase the risk of fractures, especially as CKD becomes more serious. In CKD, mineral and bone disorders (CKD-MBD) cause abnormalities in how the body processes vitamin D, calcium, phosphorus, or parathyroid hormone (PTH). It can also affect bone strength and cause calcium build-up in the soft tissues. Treatment usually starts with correcting the chemical abnormalities that occur in the body due to CKD-MBD before focusing on osteoporosis and fractures. A study review spanning 2010 to 2023 investigated optimal vitamin D supplementation doses in CKD patients, indicating varied outcomes influenced by factors like dosage, duration, and population characteristics. Doses ranged from 800 to 8,000 IU/day of cholecalciferol, with recommendations contingent on serum 25(OH)D levels.
Co-Authors Aldico J Sapardan