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All Journal HAYATI Journal of Biosciences Acta Pharmaciae Indonesia : Acta Pharm Indo Pharmacy Reports
Zulkepli, Nur Ayunie
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology

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Psidium guajava leaves extract decreased leukocytes and lymphocytes count in Complete Freund's Adjuvant-induced arthritis rats Baroroh, Hanif Nasiatul; Lesty, Rupa; Utami, Esti Dyah; Zulkepli, Nur Ayunie
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5789

Abstract

Background: Psidium guajava is one of the herbal plants that has demonstrated antioxidant and anti-inflammatory properties. Objective: This study aimed to determine the effect of P. guajava leaves extract on leukocytes and lymphocytes in rats. Methods: Fifty rats were divided into five groups. Complete Freund’s Adjuvant (CFA) was employed to generate an animal model of arthritis. Group I (arthritis control) received CMC Na, group II (positive control) received dexamethasone 3 mg/kg BW, and groups III-V received 250, 500, and 750 mg/kg BW of the ethanol extract of P. guajava leaves orally. Total leukocyte counts were calculated on days 13 and 29, and on day 29, the histological joints were inspected. Results: The P. guajava leaves extract decreased the number of lymphocytes and total leukocytes. Before and after treatment, the group receiving doses of 250 mg/kg BW and 750 mg/kg BW of the extract showed a significant decrease in leukocytes. With treatment of 250, 500, and 750 mg/kg BW of P. guajava leaves ethanol extract, the lymphocyte count was also reduced. The P. guajava leaves extract at 750 mg/kg body weight showed the greatest effectiveness in suppressing leukocytes and lymphocytes. Conclusion: The extract of P. guajava leaves has the potential to be developed as an anti-inflammatory for arthritis.
In vitro antibiofilm activity of eggshells derived nano-hydroxyapatite (nHA) against Staphylococcus aureus and Streptococcus mutans Suhaimi, Nursyamimi Nasuha; Tarmizi, Nur Hazirah; Zulkifli, Nur Farahim; Amana Allah, Nur Ili Aqilah; Harun, Fakhrul Aimanulhakim; Hanafee, Siti Nur’aisyah Muhamad; Zulkepli, Nur Ayunie; Salim, Fatimah; Mokhtar, Norehan
Pharmacy Reports Vol. 4 No. 3 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.84

Abstract

Dental caries, a highly prevalent oral health condition worldwide, is primarily driven by the biofilm-forming abilities of Staphylococcus aureus and Streptococcus mutans. The interest in eggshell extracts has grown in recent years due to their potential benefits for oral health. Therefore, this study investigated the potential of nano-hydroxyapatite (nHA) derived from eggshells in combating bacterial infections and inhibiting biofilm formation by the selected cariogenic bacteria. The antibacterial activity of the nano-hydroxyapatite extract was initially assessed using the agar well diffusion method. Subsequently, biofilm inhibition was evaluated through crystal violet assays, and the disruption of biofilm structure was visualized under a light microscope. The findings indicated that the nano-hydroxyapatite extract lacked antibacterial activity in inhibiting the growth of both S. aureus and S. mutans. However, the extract demonstrated antibiofilm activity against mono-species biofilms, with observed disruption of biofilm formation upon treatment. As a result, nano-hydroxyapatite extracts derived from eggshells may hold potential as agents for inhibiting biofilm formation associated with dental caries.
Cell Cycle Target Protein Induced by Galangin Treatment in Luminal Cells Confirmed by Bioinformatics Analysis Sekarini, Diyah Novi; Jati, Yohanes Surya; Zulkepli, Nur Ayunie; Putri, Dyaningtyas Dewi Pamungkas
HAYATI Journal of Biosciences Vol. 32 No. 4 (2025): July 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.4.969-979

Abstract

Galangin has activity modulating cell cycle arrest on luminal cancer cells and has high selectivity and low cytotoxicity for normal cells. This research intends to know galangin's prospective targets for promoting cell cycle arrest in luminal breast cancer via experimental in vitro, network pharmacology, and bioinformatics validation. In this research, MCF-7, a luminal model cell, was treated with galangin dose-dependent. Consequently, galangin exhibited a cytotoxic impact, with IC50 values of 117.86 μM. After that, SwissTargetPrediction, UALCAN, ShinyGO, and OncoLnc were used for bioinformatics validations, and Cytoscape software and the STRING website were used for computational analysis. Eight overlapping galangin target genes against luminal breast cancer were found. According to the analysis of the protein-protein interaction (PPI) network, eight hub genes-including CDK1, PLK1, TOP2A, ESR1, AURKB, NEK2, MMP9, and CA12-had the highest degree of freedom. Cell cycle regulation has been discovered to be tightly associated with overexpression of CDK1, PLK1, AURKB, and NEK2. By influencing the cell cycle, galangin inhibits the growth of luminal breast cancer, as determined by GO and KEGG enrichment analyses. In conclusion, by triggering cell cycle arrest, galangin may be used as a prospective chemotherapeutic treatment.
Co-Authors Amana Allah, Nur Ili Aqilah Dyaningtyas Dewi Putri Pamungkas Esti Dyah Utami Hanafee, Siti Nur’aisyah Muhamad Hanif Nasiatul Baroroh Harun, Fakhrul Aimanulhakim Jati, Yohanes Surya Lesty, Rupa Mokhtar, Norehan Salim, Fatimah Sekarini, Diyah Novi Suhaimi, Nursyamimi Nasuha Tarmizi, Nur Hazirah Zulkifli, Nur Farahim