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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo
Umar, Abdulganiyu
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Medicine & Pharmacology

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Characterization and tyrosinase activities of a mixture of β-sitosterol and stigmasterol from Bauhinia rufescens Lam Muhammad, Aminu; Idris, Musa Maikudi; Ali, Umar; Umar, Abdulganiyu; Sirat, Hasnah Mohd
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.6284

Abstract

Background: Phytosterols are steroid compounds present in plants that are similar to cholesterol in structure and functions. In this work, stem bark of Bauhinia rufescens was extracted with petroleum ether. Objective: This work aims to determine anti-tyrosinase activities of a mixture of β-sitosterol and stigmasterol from the stem bark B, rufescens for the treatment of dermatological disorders. Methods: This work is presenting isolation, characterization and anti-tyrosinase activities of a mixture of β-sitosterol and stigmasterol from the stem bark B. rufescens. The extract was subjected to chromatographic techniques to afford a phytosterol identified as a mixture of β-sitosterol and stigmasterol based on GC-MS, IR, 1HNMR and 13CNMR data. Results: The phytosterol isolated showed inhibition of tyrosinase activity at 57.1%±0.03 as compared to kojic acid with 85.0% ± 0.01 (sample concentrations of 0.1 mg/mL). Conclusion: The finding of this study revealed that, the mixture of β-sitosterol and stigmasterol has potential to be developed as tyrosinase inhibitors for the treatment of dermatological disorders.
Co-Authors Ali, Umar Idris, Musa Maikudi Muhammad, Aminu Sirat, Hasnah Mohd