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All Journal Radioterapi & Onkologi Indonesia Cermin Dunia Kedokteran
Sindunata, Natasha Bharat
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RADIOTHERAPY RESPONSE IN ADVANCED STAGE OF CERVICAL CANCER TYPES OF HISTOPATHOLOGY SQUAMOS CELL CARCINOMA AND ADENOCARCINOMA Sindunata, Natasha Bharat; Pratiwi, Eka Indah; lubis, arlavinda asmara
Radioterapi & Onkologi Indonesia Vol 15, No 1 (2024): Vol.15, No. 1(2024): Volume 15 No. 1 January 2024
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v15i1.158

Abstract

Background: Cervical cancer is a malignancy that occurs on the cervix, and it is the most common cancer in the world. According by GLOBOCAN in 2020, cervical cancer ranks seventh globally. The main management of advanced cervical cancer is using radiotherapy. The problem that occurs is the need for radiation for advanced cervical cancer patiens while there is still a lack of availability of radiotherapy equipment, causing under treatment management.Objective: To prove that the response to radiotherapy in patients with advanced cervical cancer types of histopathology squamous cell carcinoma is better than adenocarcinoma in Ulin General Hospital, BanjarmasinMethods: The study used an analytic observational design with a cross sectional approach. The sample was taken over the time span during the study from January 2021 to December 2022 and was taken by total sampling.Results: The total sample was 128 cervical cancer patients with 91 squamous cell carcinoma samples and 37 adenocarcinoma samples. After conducting a chi-square analysis between several variables and response to therapy, a significant relationship was found between histopathology and response to therapy, which concluded that cervical cancer with histopathology of squamous cell carcinoma is more radiosensitive than adenocarcinoma. This is due to the relationship between VEGF and radiation.Conclusion: The response of radiotherapy is more sensitive in type of histopathology squamous cell carcinoma than in cervical cancer with type of histopathology adenocarcinoma.
Respons Radioterapi Karsinoma Serviks Stadium Lanjut Jenis Sel Skuamosa dan Adenokarsinoma di RSUD Ulin, Banjarmasin, Indonesia: Hasil Penelitian Sindunata, Natasha Bharat; Pratiwi, Eka Indah; Lubis, Arlavinda Asmara
Cermin Dunia Kedokteran Vol 52 No 9 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i9.1355

Abstract

Introduction: Cervical carcinoma (cancer) is a malignancy in the cervix and is one of the most common cancers in women. Data released by GLOBOCAN in 2022 showed that cervical cancer ranks eighth globally. The main treatment for advanced cervical cancer is radiotherapy. The aim of this study is to compare the radiotherapy response in squamous cell carcinoma cervical cancer with the response in adenocarcinoma cervical cancer at Ulin Regional Hospital, Banjarmasin, Indonesia. Methods: This cross-sectional research used an analytical observational design. Total sample during the research period from January 2021 to December 2022. Results: Total of 128 cervical cancer patients consisting of 91 squamous cell carcinomas and 37 adenocarcinomas. Chi-square analysis found a significant association between histopathology and response to therapy; squamous cell carcinoma histopathology was more radiosensitive than adenocarcinoma. Conclusion: Histopathological type is the only characteristic significantly associated with radiation response, whereas age, stage, and tumor size are not significantly associated with radiation response.
Co-Authors lubis, arlavinda asmara Pratiwi, Eka Indah