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All Journal E-Jurnal Medika Udayana Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Hang Tuah Medical Journal
Poerwanto, Eka
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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PERAN TERAPI HBO TERHADAP PERBAIKAN KLINIS DAN KUALITAS HIDUP PASIEN DEPRESI devi, ismylatifa; Rahardjo, Indarwati Mulio; Ayu P, Intan Tiara; Azizah, Ismi; Mardinata P, Ivan; Nandaka, I Ketut Tirka; Poerwanto, Eka
E-Jurnal Medika Udayana Vol 13 No 07 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i07.P16

Abstract

ABSTRAK Depresi adalah gangguan mood dengan gejala merasa kosong, kelelahan yang berlebihan, hilang motivasi untuk beraktivitas hingga menimbulkan keinginan untuk bunuh diri. Berdasarkan data WHO bunuh diri pada orang depresi merupakan salah satu penyebab utama kematian pada usia produktif. Terapi Oksigen Hiperbarik (HBOT) adalah terapi pemberian oksigen 100% dalam tekanan lebih dari 1 ATA. Beberapa studi menunjukkan manfaat signifikan dari HBOT pada tubuh, salah satunya meningkatkan produksi antioksidan tubuh. Studi ini akan mengkaji lebih lanjut mengenai peran HBOT terhadap perbaikan klinis dan kualitas hidup pasien depresi yang diukur melalui kuisioner HDRS dan BDI. Desain studi adalah kuasi eksperimen, sebanyak 7 pasien dilakukan pemeriksaan tingkat depresi dengan kuisioner HDRS dan BDI. Pasien dengan skor di atas 10 (menunjukkan depresi ringan-berat) selanjutnya mengisi kuisioner untuk kualitas hidup. Setelah penilaian dengan kuisioner, pasien mendapatkan terapi oksigen hiperbarik selama 5 hari. Setelah pemberian HBOT dilakukan pemeriksaan ulang perbaikan klinis dan kualitas hidup. Hasil penelitian menunjukkan pada sebelum dan sesudah terapi HBO terdapat perubahan pada perbaikan klinis melalui penilaian HDRS (p=0.001) dan BDI (p=0.012) dan kualitas hidup pasien dengan penilaian WHOQOL domain 1 (p=0.014), domain 2 (p=0.071), domain 3 (p=0.022), domain 4 (p=0.013). Perubahan signifikan (p<0.005) pada hasil pretest dan posttest menunjukkan perbaikan klinis dan kualitas hidup pasien meningkat sebelum dan sesudah terapi HBO. Kata kunci : Depresi, Terapi Oksigen Hiperbarik, Kualitas Hidup
Perbandingan Efektivitas Platelet Rich Plasma VS Hypertonic Dextrose Prolotherapy terhadap Perbaikan Klinis Pasien Osteoartritis Genu POERWANTO, EKA; HENDRATA ERRY ANDISARI2; Rr. MUTIARA DEVANIA SAMARA QALBA; RONALD PRATAMA ADIWINOTO
Hang Tuah Medical Journal Vol 22 No 1 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i1.639

Abstract

ABSTRACT Background: Knee osteoarthritis (OA) affects mainly older individuals, causing joint degeneration and decreased mobility. While current treatments include medications and surgery, regenerative therapies like Platelet Rich Plasma (PRP) and Hypertonic Dextrose Prolotherapy (HDP) offer promising alternatives. This study aims to compare the effectiveness of PRP and HDP injections in knee OA patients, providing insights into optimal treatment choices. Methods: This experimental analytical study involved two groups of participants. Group 1 (N=20) received PRP injections three times into both knees with four-week intervals. Group 2 (N=20) received HDP injections with 20% concentration into both knees with the same intervals. Numeric Rating Scale (NRS) and Western Ontario and McMaster University Arthritis Index (WOMAC) scores were assessed before and after injections to evaluate changes in pain, stiffness, and functional limitation. Results: Both PRP and HDP injections significantly reduced NRS scores, pain, stiffness, functional limitation, and total WOMAC scores. The reduction in pain, functional limitation, and total WOMAC scores was higher with HDP, while PRP was more effective in reducing stiffness. Mild pain during injection and knee swelling were reported by some participants, but no systemic complaints were noted, and all side effects resolved within a week. Conclusion: Both PRP and HDP injections are equally effective in reducing pain and stiffness and improving function in knee OA patients. These procedures offer promising, cost-effective, and easily administered therapies for knee OA, with HDP being a more cost-efficient option compared to PRP. Keywords: Osteoarthritis, regenerative therapy, comparison
The Effect Of Ethanol Extract Of Golden Sea Cucumber (Stichopus Hermanii) On Alt Levels In Aspirin-Induced Wistar Male Rats (Rattus Norvegicus) Ferguszon, Devina Hanalily Maharani; Purwaningsari, Diah; Wienta Diarsvitri, Wienta; Poerwanto, Eka
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 19 No 1 (2025): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan (In Press)
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v19i1.10386

Abstract

Drug-induced liver injury is the most common cause of acute liver failure in the United States. Hepatocyte injury can be caused by the consumption of high doses of aspirin, leading to the formation of free radicals. Golden sea cucumber (Stichopus hermanii) can play a role in prevention of free radicals through antioxidant. The study used a post test only control group design involving 32 wistar male rats divided into 4 groups : negative control (K-), positive control (K+), and two groups treated with Stichopus hermanii extract at doses of 486 mg/kg BB (KP1) and 972 mg/kg BB (KP2) for 23 days. The results of the study with Man-Whitney test showed that neither the groups treated with Stichopus hermanii extract at both doses of 486 mg/kg BB nor 972 mg/kg BB doses of Stichopus hermanii extract led to a significant reduction in ALT levels when compared to positive control. There was no significant difference in ALT levels between the two extract doses. The conclusion of this study is the administration of Stichopus hermanii extract at doses of 486 mg/kg BB dan 972 mg/kg BB for 23 days can not reduce ALT levels in aspirin-induced experimental animal.
Co-Authors Ayu P, Intan Tiara Azizah, Ismi devi, ismylatifa Diah Purwaningsari Ferguszon, Devina Hanalily Maharani HENDRATA ERRY ANDISARI2 I KETUT TIRKA NANDAKA Mardinata P, Ivan Rahardjo, Indarwati Mulio Ronald Pratama Adiwinoto Rr. MUTIARA DEVANIA SAMARA QALBA Wienta Diarsvitri, Wienta