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All Journal Midwinerslion : Jurnal Kesehatan STIKes Buleleng International Journal of Health and Pharmaceutical (IJHP) Jurnal Pharmactive
Sindhu Aditama, I Gede Agus
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Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Other

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EFEKTIVITAS DAN KEAMANAN KOMBINASI IVERMECTIN-DIETHYLCARBAMAZINE-ALBENDAZOLE VERSUS DIETHYLCARBAMAZINE-ALBENDAZOLE ATAU ALBENDAZOLE-IVERMECTIN PADA KASUS FILARIASIS: SUATU KAJIAN CAKUPAN Sindhu Aditama, I Gede Agus; Oviani, Gusti Ayu
MIDWINERSLION Jurnal Kesehatan STIKes Buleleng Vol. 9 No. 1 (2024): MIDWINERSLION Jurnal Kesehatan STIKes Buleleng
Publisher : LPPM STIKes Buleleng

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52073/mjksb.v9i1.432

Abstract

Filariasis merupakan penyakit yang banyak dijumpai di negara tropis disebabkan oleh infeksi Wuchereria bancrofti, Brugia malayi, dan Brugia timori melalui vektor nyamuk dari genus Culex, Anopheles, dan Aedes sp. yang membawa mikrofilaria. WHO menerapkan strategi Mass Drug Administration dengan menyarankan penggunaan antiparasit seperti ivermectin, diethylcarbamazine, dan albendazole untuk pengobatan filariasis. Saat ini, pelaksanaan penelitian mengenai efektivitas dan keamanan kombinasi tiga obat ivermectin-diethylcarbamazine-albendazole [IDA] hanya melibatkan sedikit negara. Kajian ini bertujuan untuk memetakan sejauh mana bukti yang mendukung efektivitas dan keamanan penggunaan kombinasi tiga terapi Ivermectin-Diethylcarbamazine-Albendazole [IDA] dibandingkan kombinasi dua terapi Diethylcarbamazine-Albendazole [DA] atau Ivermectin-Albendazole [IA] pada subjek dengan filariasis. Suatu kajian cakupan (scoping review) dilakukan dan dilaporkan berdasarkan panduan dari PRISMA dengan pencarian artikel pada database PubMed dan ScienceDirect dengan sejumlah 8 artikel memenuhi kriteria kelayakan. Sejumlah 6 dari 8 artikel terpilih menunjukkan kombinasi IDA lebih efektif untuk terapi filariasis dibandingkan kombinasi DA atau IA, namun berdasarkan keamanan terapi dilihat dari adanya efek yang tidak dikehendaki (adverse effects/AEs) lebih sering terjadi pada kelompok IDA daripada DA atau IA. AEs yang sering terjadi berada pada tingkat ringan sampai sedang seperti kelelahan, sakit kepala, arthralgia, mual, muntah, dan nyeri abdominal. Kesimpulan kajian cakupan ini adalah kombinasi terapi IDA lebih efektif dalam pembersihan mikrofilaremia maupun perubahan negatif nilai circulating filarial antigen (CFA) dibandingkan DA atau IA. Berdasarkan keamanan terapi, pemberian IDA dapat ditolerensi dengan baik oleh subjek. AEs lebih sering terjadi pada kelompok IDA dengan jenis AEs ringan hingga sedang.
EVALUASI PEMBERIAN TERAPI NSAID PADA PASIEN OSTEOARTHRITIS DI POLI RAWAT JALAN RS WISMA PRASHANTI Indra Marangyana, I Gede Bagus; Sindhu Aditama, I Gede Agus; Widiani, Ni Putu Astuti
Journal Pharmactive Vol. 3 No. 2 (2024): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64036/pharmactive.v3i2.58

Abstract

The prevalence of osteoarthritis in Indonesia has reached quite high numbers¾5% at the age of 40 years, 30% at the age of 40-60 years, and 65% of elderly people over 61 years. Osteoarthritis occurs more often in women than men. Osteoarthritis management is recommended in certain conditions using Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). NSAIDs have various side effects such as obstruction, impaired kidney function, cardiovascular disorders, gastrointestinal disorders. Therefore, it is necessary to evaluate the use of NSAIDs regarding appropriate indications, drug selection and dosage. This study aims to determine the profile of use and evaluate the rationality of NSAID prescribing. This type of research is descriptive observational. Data collection was carried out retrospectively using medical records at Wisma Prasanthi Hospital. The subjects of this study were outpatients in the period July-December 2023 and met the inclusion criteria. The results of the study showed that the highest use of NSAIDs was the non-selective group (100%), i.e. Diclofenac Sodium (48.71%), Meloxicam (23.07%), Ibuprofen (19.23%), Caltrofen (7.69%), and Topical NSAID is Diclofenac gel (1.28%). The rationality of prescribing oral and topical NSAIDs is 100% right indication, 100% right drug selection, and 100% right dose. The conclusion from this study is that the highest use of NSAIDs is the non-selective NSAID group and the rationality for correct indications, correct drug selection and correct dosage is 100%.
Optimization of Nanogel Formulation of Piper Nigrum And Erythrina Subumbrans Extract As Anti-Inflammatory Based On Lontar Usadha Tiwang: Effectiveness Test On Mus Musculus Sindhu Aditama, I Gede Agus; Ayu Ratih Listiani, Putu
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.454

Abstract

Public health in Bali has long been supported by traditional medicine based on local wisdom, one of which is usadha tiwang. In practice, usadha tiwang uses black pepper (Piper nigrum) and dadap leaves (Erythrina subumbrans) to treat mokan disease, which is characterized by swelling and pain, typical symptoms of inflammation. Scientifically, both have been proven to have anti-inflammatory activity in both extract and cream preparations, although their use in topical nanogel formulations has not been explored. This study aims to conduct phytochemical screening, develop a combination nanogel formulation of P. nigrum and E. subumbrans extracts, and evaluate anti-inflammatory activity in vivo. Extraction was performed by maceration, using 96% ethanol (1:5) for P. nigrum and 70% ethanol (1:5) for E. subumbrans. A total of six nanogel formulas were prepared with varying gel base concentrations. Activity testing was performed on mice (Mus musculus) with 1% carrageenan induction on the paw, divided into eight groups (F1–F6, negative control, and positive control). Edema evaluation was performed using a plethysmometer, and the data were analyzed using the Kruskal-Wallis test. Screening results showed that P. nigrum ethanol extract contained alkaloids, flavonoids, and steroids, while E. subumbrans extract contained alkaloids, flavonoids, saponins, and steroids. All formulations had transmittance values ​​>90%. Statistical analysis showed a significant difference between treatment groups (p=0.002). The positive control (Voltaren® Emulgel) differed significantly from all test groups (p=0.000). Of the six formulas, F3 showed the most optimal effect with an inflammation inhibition percentage of 100% at the 60th minute of observation.
Co-Authors Ayu Ratih Listiani, Putu Indra Marangyana, I Gede Bagus Oviani, Gusti Ayu Widiani, Ni Putu Astuti