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Sukairi, Ahmad H.
Indonesian Journal of Pharmaceutical Science and Technology
Computer Science & IT Medicine & Pharmacology

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Cytotoxicity and Antimicrobial Activity of Propolis from Trigona itama Stingless Bees against Staphylococcus aureus and Escherichia coli Yusop, Syed A. T. W.; Asaruddin, Mohd R.; Sukairi, Ahmad H.; Sabri, Wan M. A. W.
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (707.484 KB) | DOI: 10.15416/ijpst.v1i1.16118

Abstract

Trigona itama is a stingless bees that produce honey which has been used widely as a traditional medicine. Due to limited research and knowledge on T. itama propolis, it becomes less popular in industrial production than honeybee propolis. The aim of this study was to identify the antibacterial activity and toxicity level in hexane, ethyl acetate and methanol extracts of T.itama propolis. T.itama propolis crude extract was tested for antibacterial activity by using disk di usion method. The antibacterial activities were assessed according to the inhibitory zone of agar medium with sample concentration of 1000 μg/mL, 750 μg/mL and 500 μg/mL. The result from this study revealed that all T. itama propolis crude extract shows presence of inhibition zone against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The brine shrimp lethality test was used to monitor the toxicity level of T. itama propolis where methanol, ethyl acetate and hexane fraction showed low activity of toxicity where all crude extract LC50 showed above 250 μg/mL. It could be concluded from this study that extract from T. itama propolis possessed antimicrobial activity and low level of toxicity. Key Words: Escherichia coli, propolis, stingless bees, Staphylococcus aureus, Trigona itama
Antioxidant and Cytotoxicity Studies of Nypa fruticans (Nypa Palm Sugar) Extract Sabri, Wan M. A. W.; Asaruddin, Mohd R. Asaruddin R.; Sukairi, Ahmad H.; Yusop, Syed A. T. W.
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (381.032 KB) | DOI: 10.15416/ijpst.v1i1.17246

Abstract

Nypa fruticans Wurmb which belongs to the family of Arecaceae is one of the most widely distributed and useful palm in the mangrove forests in the Southeast Asia. Nypa palm sugar or commonly known as “Gula Apong” was processed using nypa palm sap as raw material. The nypa palm sugar was expected to benefit wider community as source of alternative sweetener. In this study, 2, 2-diphenyl1-picryhydrazyl (DPPH) scavenging activity and cytotoxicity test of methanol extract of nypa palm sugar were conducted. The antioxidant activity was determined based on DPPH scavenging activity of extract. The cytotoxicity test was conducted against brine shrimp Artemia salina, and the LC50 value of the extract was calculated. The antioxidant activity showed that the EC50 of nypa palm sugar was 1304 mg/mL while the value of EC50 for ascorbic acid was 0.6112 mg/mL. The results of the cytotoxicity showed that the methanol extract of nypa palm sugar was interpreted as non-toxic as the value of LC50 was 184.0 mg/mL.Keywords: 2,2-diphenyl-1-picryhydrazyl, antioxidant, cytotoxicity, Nypa fruticans, nypa palm sugar
Co-Authors Asaruddin, Mohd R. Asaruddin, Mohd R. Asaruddin R. Sabri, Wan M. A. W. Yusop, Syed A. T. W.