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All Journal Jurnal Penelitian Farmasi dan Herbal Jurnal Pengabdian Masyarakat Putri Hijau
Gultom, Evi Deviana
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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SOSIALISASI DAN PEMBERIAN MINUMAN HERBAL JAHE SEBAGAI PENURUNAN TEKANAN DARAH DI POSYANDU LANSIA DESA ARA CONDONG DUSUN 7 WONOGIRI KABUPATEN LANGKAT Gultom, Evi Deviana
Jurnal Pengabdian Masyarakat Putri Hijau Vol 4 No 1 (2023): Jurnal Pengabdian Masyarakat Putri Hijau
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v4i1.1636

Abstract

Hypertension is one of the most common cardiovascular diseases suffered by the community. Hypertension is now a major problem for all of us, not only in Indonesia but in the world, because if it is not controlled properly it can be a risk factor for the emergence of complications such as heart, kidney failure, diabetes, stroke, retinopathy, nervous disorders and cerebral disorders. The increase in cases of hypertension can be caused by many factors, one of which is public knowledge that is not limited to hypertension, but what efforts can be made by the community to prevent and lower blood pressure. One of the efforts to increase people's knowledge is through counseling methods so that they are able to adopt a healthy lifestyle to improve their health. The purpose of this article is to obtain an overview of public knowledge about hypertension and to introduce herbal drinks from ginger that can lower blood pressure. The method was carried out with interactive counseling which was carried out at the Children's Poling Village Hall, Ara Condong village Langkat district, Dairi Regency using leaflet media, , and giving ginger drinks. The counseling was carried out smoothly and gave good results, where many people asked questions about their hypertension, how to avoid increasing blood pressure and trying to understand how to make the given ginger drink.
Uji Efektivitas Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Sebagai Antihiperurisemia Pada Tikus Putih Jantan Yang Di Induksi Kalium Oksonat Gultom, Evi Deviana
Jurnal Penelitian Farmasi & Herbal Vol 6 No 1 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i1.1546

Abstract

Kersen plant (Muntingia calabura L.) is a plant that has many properties and is useful as medicine. Hyperuricemia is a condition where there is an increase in uric acid levels above normal. The leaf part of this plant is widely used by the community as a traditional medicine because of its metabolite compounds. Flavonoid compounds in cherry leaves can reduce uric acid levels through inhibition of the xanthine oxidase enzyme, an enzyme that acts as a catalyst in the oxidation process of hypoxanthine to xanthine and then to uric acid. By inhibiting the work of the xanthine oxidase enzyme, the formation of uric acid will also be inhibited. This study aims to determine the effectiveness of cherry leaf ethanol extract in reducing uric acid levels in male white rats induced by potassium oxonate. This study used an experimental method using 25 male white rats induced by potassium oxonate. The test animals were divided into 5 groups: negative control (CMC Na 1%), positive control (Allopurinol), EEDK dose of 300 mg/kgBB, EEDK dose of 400 mg/kgBB, EEDK dose of 500 mg/kgBB. Measurement of uric acid levels in rats using the point of care testing (POCT) method. All data obtained were analyzed statistically using the One Way Anova test. The results of the analysis showed that there were significant differences between the negative control, positive control, EEDK 300 mg/kg, EEDK 400 mg/kg, and EEDK 500 mg/kg (P<0.05). The most effective dose of cherry leaf ethanol extract as an antihyperuricemia is the EEDK dose of 500 mg/kg BW. There was no significant difference between EEDK 400 mg/kgBW, EEDK 500 mg/kgBW and positive control (P>0.05). Based on the results of the analysis that has been done, it can be concluded that the ethanol extract of cherry leaves has an antihyperuricemia effect in rats. Keywords: Cherry leaves, Hyperuricemia, Potassium oxonate
UJI EFEKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Gultom, Evi Deviana
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2733

Abstract

Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol daun pepaya (EEDP) terhadap penurunan kadar glukosa darah pada tikus putih jantan (Rattus norvegicus) yang diinduksi aloksan, menentukan dosis yang paling efektif, dan membandingkannya dengan glibenklamid. Penelitian ini menggunakan metode eksperimen dengan rancangan post-test only control group design. Sampel daun pepaya dikumpulkan secara purposive dari Kabupaten Batu Bara, diolah menjadi obat sederhana, dan diekstraksi menggunakan metode maserasi dengan etanol 96%. Skrining fitokimia menunjukkan bahwa EEDP mengandung flavonoid, alkaloid, saponin, tanin, dan steroid/triterpenoid. Hewan uji dibagi menjadi lima kelompok: kontrol negatif (CMC Na 0,5%), kontrol positif (glibenklamid 0,45 mg/kgBB), dan tiga kelompok perlakuan dosis EEDP 100, 200, dan 400 mg/kgBB. Induksi diabetes dilakukan dengan menggunakan aloksan monohidrat. Kadar glukosa darah diukur menggunakan glukometer sebelum dan sesudah perlakuan. Hasil penelitian menunjukkan bahwa pemberian EEDP pada ketiga dosis mampu menurunkan kadar glukosa darah secara signifikan dibandingkan dengan kontrol negatif. Dosis 400 mg/kgBB memberikan penurunan paling besar dan mendekati efektivitas glibenklamid. Uji statistik tidak menunjukkan perbedaan yang signifikan antara kelompok EEDP pada dosis 400 mg/kgBB dan glibenklamid (p>0,05), yang mengindikasikan bahwa efek antidiabetik EEDP sebanding dengan obat konvensional. Mekanisme penurunan glukosa darah diduga terkait dengan kemampuan flavonoid untuk meningkatkan sensitivitas insulin, melindungi sel β pankreas, dan menghambat enzim α-glukosidase. Sebagai kesimpulan, EEDP berpotensi sebagai agen antidiabetik alami, dengan dosis optimal 400 mg/kgBB, yang efektivitasnya sebanding dengan glibenklamid. Temuan ini mendukung penggunaan daun pepaya sebagai obat tradisional yang aman, terjangkau, dan mudah didapat, serta membuka peluang untuk penelitian lebih lanjut dalam pengembangan fitofarmaka antidiabetik.
EDUKASI DAN PELATIHAN PEMBUATAN TEH HERBAL DARI BUNGA KECOMBRANG SEBAGAI UPAYA PENCEGAHAN DAN PENGENDALIAN DIABETES MELLITUS Gultom, Evi Deviana
Jurnal Pengabdian Masyarakat Putri Hijau Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat Putri Hijau (JPMPH)
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v6i1.2680

Abstract

Diabetes mellitus is a serious health problem in Indonesia, which ranks fifth in the world for the highest number of diabetics. The high prevalence, along with the side effects and cost of pharmacological treatments, encourages the need for supportive alternatives. This community service aims to increase the understanding and awareness of the Mekar Sari Village community regarding the prevention and management of diabetes mellitus through the utilization of torch ginger flower (Etlingera elatior) as an herbal tea. Torch ginger flower contains bioactive compounds such as flavonoids and polyphenols that have anti-hyperglycemic potential by inhibiting α-glucosidase and α-amylase enzymes. This activity will be held on Friday, September 26, 2025, at the Mekar Sari Village Office in Deli Tua. The methods used include health education, training on how to make the herbal tea, a question-and-answer session, and health screening. Through this activity, it is expected that the community can independently utilize torch ginger flower as a supportive therapy that is easy to process, affordable, and holistic to control diabetes mellitus and improve their quality of health.
UJI EFEKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Gultom, Evi Deviana
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2733

Abstract

Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol daun pepaya (EEDP) terhadap penurunan kadar glukosa darah pada tikus putih jantan (Rattus norvegicus) yang diinduksi aloksan, menentukan dosis yang paling efektif, dan membandingkannya dengan glibenklamid. Penelitian ini menggunakan metode eksperimen dengan rancangan post-test only control group design. Sampel daun pepaya dikumpulkan secara purposive dari Kabupaten Batu Bara, diolah menjadi obat sederhana, dan diekstraksi menggunakan metode maserasi dengan etanol 96%. Skrining fitokimia menunjukkan bahwa EEDP mengandung flavonoid, alkaloid, saponin, tanin, dan steroid/triterpenoid. Hewan uji dibagi menjadi lima kelompok: kontrol negatif (CMC Na 0,5%), kontrol positif (glibenklamid 0,45 mg/kgBB), dan tiga kelompok perlakuan dosis EEDP 100, 200, dan 400 mg/kgBB. Induksi diabetes dilakukan dengan menggunakan aloksan monohidrat. Kadar glukosa darah diukur menggunakan glukometer sebelum dan sesudah perlakuan. Hasil penelitian menunjukkan bahwa pemberian EEDP pada ketiga dosis mampu menurunkan kadar glukosa darah secara signifikan dibandingkan dengan kontrol negatif. Dosis 400 mg/kgBB memberikan penurunan paling besar dan mendekati efektivitas glibenklamid. Uji statistik tidak menunjukkan perbedaan yang signifikan antara kelompok EEDP pada dosis 400 mg/kgBB dan glibenklamid (p>0,05), yang mengindikasikan bahwa efek antidiabetik EEDP sebanding dengan obat konvensional. Mekanisme penurunan glukosa darah diduga terkait dengan kemampuan flavonoid untuk meningkatkan sensitivitas insulin, melindungi sel β pankreas, dan menghambat enzim α-glukosidase. Sebagai kesimpulan, EEDP berpotensi sebagai agen antidiabetik alami, dengan dosis optimal 400 mg/kgBB, yang efektivitasnya sebanding dengan glibenklamid. Temuan ini mendukung penggunaan daun pepaya sebagai obat tradisional yang aman, terjangkau, dan mudah didapat, serta membuka peluang untuk penelitian lebih lanjut dalam pengembangan fitofarmaka antidiabetik.
FORMULASI DAN UJI EFEKTIVITAS ANTIBAKTERI TERHADAP SEDIAAN Deodorant Spray EKSTRAK ETANOL BATANG SERAI WANGI (Cymbopogon nardus L.) TERHADAP BAKTERI Staphylococcus aureus Gultom, Evi Deviana
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstract Body odor is one of the personal hygiene problems caused by bacterial activity such as Staphylococcus aureus on sweat. Continuous use of chemical-based deodorants may cause skin irritation; therefore, natural alternatives are needed. This study aims to formulate and evaluate the antibacterial effectiveness of a deodorant spray preparation made from citronella (Cymbopogon nardus L.) stem ethanol extract. The extract was obtained using the maceration method with 96% ethanol, followed by phytochemical screening to identify active compounds. The deodorant spray was formulated in three extract concentrations—5%, 10%, and 15%—and evaluated for organoleptic properties, pH, drying time, spray power, and homogeneity. The antibacterial effectiveness test against Staphylococcus aureus was carried out using the disc diffusion method. The results showed that all formulas met the physical evaluation requirements of deodorant preparations. The largest inhibition zone was observed in the formula containing 15% extract, with a diameter of 16.33 mm, categorized as strong inhibitory activity. Therefore, the ethanol extract of Cymbopogon nardus stem has the potential to be used as an active ingredient in natural antibacterial deodorant spray formulations against Staphylococcus aureus.
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