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Choudhary, Manjusha
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Medicine & Pharmacology

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Enhancement of curcumin's physicochemical properties by developing its eutectic mixtures Ahlawat, Sunita; Budhwar, Vikas; Choudhary, Manjusha
Journal of Applied Pharmaceutical Research Vol. 12 No. 1 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.1.71.81

Abstract

Background: Curcumin is a compound obtained from the rhizomes of Curcuma Longa. It has various pharmacological properties like anti-inflammatory, anti-oxidant, anti-hyperlipidemic, etc. However, it also has some limitations that restrict its use as a medicine. Material and method: In the present study, a eutectic mixture of curcumin and glycine (35% and 65%) was prepared to improve its dissolution rate and photostability, characterized by DSC, FTIR, and XRD studies. Result and discussion: After 40 minutes, the eutectic mixture dissolved 10-fold more than the parent drug. The photostability studies were conducted according to ICH Q1B guidelines; after the seventh day of accelerated photostability studies, curcumin-glycine eutectic mixtures showed 36% degradation, 34% less than pure curcumin. Conclusion: The present study revealed that the physicochemical properties of BCS class II drugs can be improved by forming an eutectic mixture.
Co-Authors Ahlawat, Sunita Budhwar, Vikas