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All Journal Journal of Applied Pharmaceutical Research
Bakshi, Vasudha
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Medicine & Pharmacology

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Formulation, development, and characterization of loratadine emulgel Sharaff, Chandana Setty; Renukuntla, Pranay; Peddapalli, Himabindu; Kuchukuntla, Mounika; Bakshi, Vasudha; Jadi, Rajendra Kumar
Journal of Applied Pharmaceutical Research Vol. 12 No. 2 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.2.42.50

Abstract

Background: This study was to develop loratadine (LTD) emulgels to treat localized skin allergy. Method: Initially oil-in-water emulsion was prepared by 3 different types of surfactants & finally gelling agent carbopol 940 was incorporated into emulsion to produce emulgel (i.e., standard conventional method). Results: The developed formulations were characterized using various parameters including particle size (PS), zeta potential (ZP), polydispersity index (PDI), entrapment efficacy (EE), pH, extrusion efficacy, physical stability, in-vitro drug release studies, and scanning electron microscopy (SEM). PS, EE, PDI, ZP and In-vitro studies ranges between 186.25 ± 6.42 mm (LE-F4) to 395.24 ± 8.64 mm (LE-F1), 62.38 ± 0.36 % (LE-F2) to 76.48 ± 0.69 % (LE-F4), 0.276 ± 0.02 (LE-F4) to 0.652 ± 0.02 (LE-F1), 16.45 ± 2.13 mV (LE-F1) to 29.46 ± 2.78 mV (LE-F3) and 21.90 ± 0.3 % (LE-F1) to 68.30±0.9 % (LE-F4) respectively. Conclusion: Based on all physicochemical properties, LE-F4 formulation was considered to be optimized with minimum PS (186.25±6.42 nm), PDI (0.276±0.02), satisfactory positive surface charge (23.15 ± 1.89 mV) and maximum EE (76.48±0.69 %). FTIR studies were confirmed that there is no physical interaction between drug and excipients and SEM studies revealed that vesicle size was spherical with smooth texture. A significantly greater rate of drug release (i.e., 68.30 ± 0.90%) was seen in the LTD emulgels that were made with cationic surfactant (i.e., LE-F4) and found to be good spreadability and extrudability.
Development of abemaciclib-encapsulated nanosponges for breast cancer: optimization, drug release kinetics, and in vitro efficacy Bolledla, Nirosha; Bakshi, Vasudha
Journal of Applied Pharmaceutical Research Vol. 13 No. 4 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i4.1234

Abstract

Background: Abemaciclib (ABC) is a new, orally administered pharmaceutical agent authorised for the purpose of combating breast cancer. The drug's low bioavailability necessitates dosing two to three times daily, which may reduce patient compliance. To lessen the severity of side effects and prolong the duration of action, sustained-release formulations are required. Developing an ABC sustained-release nanoparticle system was the primary goal of this study. Methodology: Both the sustained-release polymer (EC) and the surfactant (KP-188) were derived from ethyl cellulose, in an emulsion-solvent diffusion synthesis of nanosponges (NS). We examined the impact of varying surfactant concentrations and drug-to-polymer ratios on PS, PDI, ZP, %EE, %DL, particle size, drug loading, zeta potential, and polydispersity index. Results and Discussion: The optimized formulation (F11) achieved an entrapment efficiency of 86.52±0.25% and a cumulative drug release of 77.12% over 24 hours. The drug release followed a sustained pattern over 24 hours. It best fits the Higuchi kinetic model, which indicates that drug diffusion was the primary mechanism of release from the matrix system. The MTT experiment demonstrated that ABC might be a viable cytotoxic nanocarrier for breast cancer cells from humans, specifically MCF-7 and MDA-MB-231. On top of that, following contact with storage settings of 25, 5, and 45 °C for six months, ABC maintained its drug release property with no modification in the percentage release. Conclusion: This study shows that the created NS could effectively transport and release ABC, amplifying its impact in the battle against breast cancer.
Co-Authors Bolledla, Nirosha Jadi, Rajendra Kumar Kuchukuntla, Mounika Peddapalli, Himabindu Renukuntla, Pranay Sharaff, Chandana Setty