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All Journal Medicinus : Jurnal Kedokteran
Enggalhardjo, Muljani
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Medicine & Pharmacology Public Health

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A Systematic Review of Efficacy and Safety of Difelikefalin in Treating Pruritus in Hemodialysis Patients with Chronic Kidney Disease Enggalhardjo, Muljani; Tumiwa, Gabriella Hilary; Khosasih, Yeshiza
Medicinus Vol 13, No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8109

Abstract

Background: Chronic Kidney Disease (CKD) is a type of kidney disease that gradual loss of kidney function over a period of months or years, usually more than 3 months. Uremic pruritus or chronic kidney disease-associated with CKD (CKD-aP) is a common complication that experienced by CKD patients especially for patients undergoing haemodialysis and it will negatively impact quality of life, for example depression, poor sleep quality, and miss dialysis sessions.Methods: Three online databases were used for the literature search: Science Direct, Embase, and PubMed. obtaining the information in January 2024. Using specific keywords, a comprehensive analysis of research articles was carried out. We examined the safety and effectiveness of difelikefalin in the management of pruritus in patients receiving hemodialysis who have chronic kidney disease.Result: Six studies were evaluated that met the criteria for inclusion. The efficacy of difelikefalin in all studies was examined by using WI-NRS as assessment tools for the primary outcome, and for the secondary outcome, skindex-10 or skindex-16 scoring, the 5-D itch scale, and the itch MOS (Medical Outcome Study) sleep disturbance scale were used. From all studies, difelikefalin in various dosages and routes (oral and intravenous) improved pruritus reduction in hemodialysis patients with CKD over placebo. However, in the majority of cases, difelikefalin caused a higher chance of experiencing adverse events than in the placebo group.Conclusions: All studies show a greater pruritus reduction in hemodialysis patients receiving therapy over placebo, with the optimal benefit-risk at 0.5 μg/kg of difelikefalin, despite unclear efficacy-dosage connections.
Prevalence and Risk Factors of Occupational Contact Dermatitis in Healthcare Workers Enggalhardjo, Muljani; Setiawan, Alan Dwi; Christianto, Putra Niko Laksamana Oceano
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8886

Abstract

Background: Occupational contact dermatitis (OCD) is prevalent among healthcare workers, especially during the COVID-19 pandemic. Symptoms include dryness, itchiness, and redness, with hands being the most affected. Risk factors include frequent hand washing, increased glove use, allergies, and lack of health and safety training. This review emphasizes the need for targeted prevention strategies and awareness programs.Methods: We conducted a systematic review using PubMed, focusing on studies involving healthcare workers and OCD. Keywords included "occupational contact dermatitis," "contact dermatitis," "healthcare workers," and "risk factors for OCD." Data were collected using a structured, interviewer-administered questionnaire, including the Nordic Occupational Skin Questionnaire (NOSQ-2002).Result: The review included 2,706 healthcare workers. Hand dermatitis was the most common, affecting 22% of participants. Key risk factors were a personal history of allergies, frequent hand washing, high glove usage, and insufficient health and safety training.Conclusions: This review identifies significant risk factors for OCD among healthcare workers, highlighting the need for interventions focused on reducing hand washing frequency, managing glove use, and improving health and safety training.
Prevalence and Risk Factors of Occupational Contact Dermatitis in Healthcare Workers Enggalhardjo, Muljani; Setiawan, Alan Dwi; Christianto, Putra Niko Laksamana Oceano
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8886

Abstract

Background: Occupational contact dermatitis (OCD) is prevalent among healthcare workers, especially during the COVID-19 pandemic. Symptoms include dryness, itchiness, and redness, with hands being the most affected. Risk factors include frequent hand washing, increased glove use, allergies, and lack of health and safety training. This review emphasizes the need for targeted prevention strategies and awareness programs.Methods: We conducted a systematic review using PubMed, focusing on studies involving healthcare workers and OCD. Keywords included "occupational contact dermatitis," "contact dermatitis," "healthcare workers," and "risk factors for OCD." Data were collected using a structured, interviewer-administered questionnaire, including the Nordic Occupational Skin Questionnaire (NOSQ-2002).Result: The review included 2,706 healthcare workers. Hand dermatitis was the most common, affecting 22% of participants. Key risk factors were a personal history of allergies, frequent hand washing, high glove usage, and insufficient health and safety training.Conclusions: This review identifies significant risk factors for OCD among healthcare workers, highlighting the need for interventions focused on reducing hand washing frequency, managing glove use, and improving health and safety training.
A Systematic Review of Efficacy and Safety of Difelikefalin in Treating Pruritus in Hemodialysis Patients with Chronic Kidney Disease Enggalhardjo, Muljani; Tumiwa, Gabriella Hilary; Khosasih, Yeshiza
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.8109

Abstract

Background: Chronic Kidney Disease (CKD) is a type of kidney disease that gradual loss of kidney function over a period of months or years, usually more than 3 months. Uremic pruritus or chronic kidney disease-associated with CKD (CKD-aP) is a common complication that experienced by CKD patients especially for patients undergoing haemodialysis and it will negatively impact quality of life, for example depression, poor sleep quality, and miss dialysis sessions.Methods: Three online databases were used for the literature search: Science Direct, Embase, and PubMed. obtaining the information in January 2024. Using specific keywords, a comprehensive analysis of research articles was carried out. We examined the safety and effectiveness of difelikefalin in the management of pruritus in patients receiving hemodialysis who have chronic kidney disease.Result: Six studies were evaluated that met the criteria for inclusion. The efficacy of difelikefalin in all studies was examined by using WI-NRS as assessment tools for the primary outcome, and for the secondary outcome, skindex-10 or skindex-16 scoring, the 5-D itch scale, and the itch MOS (Medical Outcome Study) sleep disturbance scale were used. From all studies, difelikefalin in various dosages and routes (oral and intravenous) improved pruritus reduction in hemodialysis patients with CKD over placebo. However, in the majority of cases, difelikefalin caused a higher chance of experiencing adverse events than in the placebo group.Conclusions: All studies show a greater pruritus reduction in hemodialysis patients receiving therapy over placebo, with the optimal benefit-risk at 0.5 μg/kg of difelikefalin, despite unclear efficacy-dosage connections.
Co-Authors Christianto, Putra Niko Laksamana Oceano Khosasih, Yeshiza Setiawan, Alan Dwi Tumiwa, Gabriella Hilary