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All Journal Veterinary Biomedical and Clinical Journal
Supriyanto, Melda Putri Elizabeth
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Veterinary

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Effect of Torbangun Leaf (Coleus ambonicus, L.) Extract Feeding on Cisplatin-Induced in Wistar Rats (Rattus norvegicus): Gambaran Histopatologi Ginjal yang Diinduksi Cisplatin dan Ekstrak Daun Torbangun (Coleus ambonicus, L.) pada Tikus Wistar (Rattus norvegicus) Solfaine, Rondius; Supriyanto, Melda Putri Elizabeth
Veterinary Biomedical and Clinical Journal Vol. 4 No. 1 (2022)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2022.004.01.2

Abstract

This study aimed to analyze the effect of torbangun leaf extract (Coleus ambonicus, L.) on kidney histopathology in cisplatin-induced Wistar rats. The design used was Completely Randomized Design (CRD) with three different treatments and six repetitions. The rats used were 18 male Wistar (Rattus norvegicus) rats, bodyweight 150-200 grams and 2-3 months of age. Treatment P0 for Wistar rats given aquadest ad libitum, P1 for Wistar rats injected with Cisplatin on day 4, intraperitoneally at a dose of 7 mg/kg with 1% of CMC NA suspension and P2 for Wistar rats given Torbangun leaf extract orally at a dose of 100 mg/kg BW for seven days. On day 4, groups P1 and P2 were injected with Cisplatin intraperitoneally at a 7 mg/kg BW. The non-parametric data from the study were statistically tested with the Kruskal Wallis test and the post hoc test in the form of the Mann-Whitney test. The test results from statistical analysis showed that the Torbangun leaf extract could reduce tissue damage by significantly reducing hemorrhage, congestion, and vasculitis in the treatment group
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