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Daffa, Muhammad B.
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Hydroxyurea therapy for children with sickle cell anemia: A systematic review and meta-analysis Khansa, Firyal; Ghifari, Muhammad H.; Daffa, Muhammad B.; Nasywa, Fiola; Enitan, Seyi S.; Eleojo , Itodo G.; Ali, Mazen EI.
Narra X Vol. 2 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i2.164

Abstract

Sickle cell anemia (SCA) is a major global health issue, particularly among pediatric population, influenced by factors such as malaria susceptibility and genetic distribution. On the other hand, hydroxyurea therapy has been a well-established and accepted treatment for SCA, with over 25 years of clinical experience. It has been proven to be safe and effective in preventing vaso-occlusive events and chronic organ damage. The aim of this study was to assess the efficacy of hydroxyurea in alleviating pediatric SCA. This study was comprised of a systematic literature search and meta-analysis in accordance with the PRISMA and the Cochrane Handbook guidelines. A systematic search was performed on PubMed, Cochrane, and ScienceDirect databases for relevant literature published as of January 2024. Placebo-controlled clinical trials reporting the efficacy of hydroxyurea in managing SCA among pediatric patients were included in the systematic review. The eligible studies were further assessed for its reporting quality using Risk of Bias 2.0. Pooled analysis was carried out using a random effect model, where the effect size was calculated based on the mean difference (MD) and 95% confidence interval (95%CI). Three randomized clinical trials comprised of 423 participants were included in the studies. Among patients receiving hydroxyurea, significant improvement was observed in fetal hemoglobin (HbF) with MD of 9.45% (95%CI: 2.15–16.75), but not in mean corpuscular volume (MCV) (MD=8.77 fL (95%CI: -28.85–46.39). Hydroxyurea also significantly reduced white blood cell (WBC) (MD=-4.21 cells/mm3; 95%CI: -5.68–-2.93), absolute neutrophil count (ANC) (MD=-1.43 cells/mm3; 95%CI: -2.11–-0.74), absolute reticulocyte count (ARC) (MD=-141.85 cells/mm3; 95%CI; -172.77–-110.94), and platelet count (MD=-74.92 cells/mm3; 95%CI: -117.05–-32.78). In conclusion, hydroxyurea is efficacious in treating pediatric SCA, as observed in the HbF, WBC, ANC, ARC, and platelet count.
Global prevalence of natural disaster-induced acute respiratory infections: A systematic review and meta-analysis of 290,380 participants Daffa, Muhammad B.; Khansa, Firyal; Ghifari, Muhammad H.; Zaskia, Siti R.; Jung, Yoonju
Narra X Vol. 2 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i3.181

Abstract

Acute respiratory infections (ARI) can be caused by the occurrence of natural disasters such as earthquakes, volcanic eruptions, landslides, tsunamis, floods, and droughts. The aim of this study was to determine the global prevalence of acute respiratory infections during post-natural disasters across countries. A systematic review and meta-analysis were conducted in accordance with the PRISMA guidelines. Studies reporting acute respiratory infections prevalence in natural disaster-impacted areas were identified and screened from PubMed, Scopus, Crosreff, Scilit, and medRxiv as of March 16th, 2024. The meta-analysis was conducted using the Freeman-Tukey double arcsine transformation with a random-effects model. A total of 15 out of 2,052 studies, covering 290,380 subjects, were included in the meta-analysis. The pooled estimate of acute respiratory infection prevalence following natural disasters across multiple countries was 43.0% (95% confidence interval (CI): 31–55%; p-Het<0.01; I²=99.97%). No statistical significance was observed between subgroups, including population density (p=0.281), country income (p=0.583), and types of disasters (p=0.468), suggesting the indiscriminate nature of disaster-induced acute respiratory infections. The highest prevalence was observed in studies from 2015–2019, with a prevalence of 52% (95%CI: 32.7–72.2%; p-Het<0.001; I²=99.97%). In conclusion, the global prevalence of disaster-induced ARI is considered high, reaching 43%, highlighting the need for countermeasures to address these diseases during disasters.
Hydroxyurea therapy for children with sickle cell anemia: A systematic review and meta-analysis Khansa, Firyal; Ghifari, Muhammad H.; Daffa, Muhammad B.; Nasywa, Fiola; Enitan, Seyi S.; Eleojo , Itodo G.; Ali, Mazen EI.
Narra X Vol. 2 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i2.164

Abstract

Sickle cell anemia (SCA) is a major global health issue, particularly among pediatric population, influenced by factors such as malaria susceptibility and genetic distribution. On the other hand, hydroxyurea therapy has been a well-established and accepted treatment for SCA, with over 25 years of clinical experience. It has been proven to be safe and effective in preventing vaso-occlusive events and chronic organ damage. The aim of this study was to assess the efficacy of hydroxyurea in alleviating pediatric SCA. This study was comprised of a systematic literature search and meta-analysis in accordance with the PRISMA and the Cochrane Handbook guidelines. A systematic search was performed on PubMed, Cochrane, and ScienceDirect databases for relevant literature published as of January 2024. Placebo-controlled clinical trials reporting the efficacy of hydroxyurea in managing SCA among pediatric patients were included in the systematic review. The eligible studies were further assessed for its reporting quality using Risk of Bias 2.0. Pooled analysis was carried out using a random effect model, where the effect size was calculated based on the mean difference (MD) and 95% confidence interval (95%CI). Three randomized clinical trials comprised of 423 participants were included in the studies. Among patients receiving hydroxyurea, significant improvement was observed in fetal hemoglobin (HbF) with MD of 9.45% (95%CI: 2.15–16.75), but not in mean corpuscular volume (MCV) (MD=8.77 fL (95%CI: -28.85–46.39). Hydroxyurea also significantly reduced white blood cell (WBC) (MD=-4.21 cells/mm3; 95%CI: -5.68–-2.93), absolute neutrophil count (ANC) (MD=-1.43 cells/mm3; 95%CI: -2.11–-0.74), absolute reticulocyte count (ARC) (MD=-141.85 cells/mm3; 95%CI; -172.77–-110.94), and platelet count (MD=-74.92 cells/mm3; 95%CI: -117.05–-32.78). In conclusion, hydroxyurea is efficacious in treating pediatric SCA, as observed in the HbF, WBC, ANC, ARC, and platelet count.
Global prevalence of natural disaster-induced acute respiratory infections: A systematic review and meta-analysis of 290,380 participants Daffa, Muhammad B.; Khansa, Firyal; Ghifari, Muhammad H.; Zaskia, Siti R.; Jung, Yoonju
Narra X Vol. 2 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i3.181

Abstract

Acute respiratory infections (ARI) can be caused by the occurrence of natural disasters such as earthquakes, volcanic eruptions, landslides, tsunamis, floods, and droughts. The aim of this study was to determine the global prevalence of acute respiratory infections during post-natural disasters across countries. A systematic review and meta-analysis were conducted in accordance with the PRISMA guidelines. Studies reporting acute respiratory infections prevalence in natural disaster-impacted areas were identified and screened from PubMed, Scopus, Crosreff, Scilit, and medRxiv as of March 16th, 2024. The meta-analysis was conducted using the Freeman-Tukey double arcsine transformation with a random-effects model. A total of 15 out of 2,052 studies, covering 290,380 subjects, were included in the meta-analysis. The pooled estimate of acute respiratory infection prevalence following natural disasters across multiple countries was 43.0% (95% confidence interval (CI): 31–55%; p-Het<0.01; I²=99.97%). No statistical significance was observed between subgroups, including population density (p=0.281), country income (p=0.583), and types of disasters (p=0.468), suggesting the indiscriminate nature of disaster-induced acute respiratory infections. The highest prevalence was observed in studies from 2015–2019, with a prevalence of 52% (95%CI: 32.7–72.2%; p-Het<0.001; I²=99.97%). In conclusion, the global prevalence of disaster-induced ARI is considered high, reaching 43%, highlighting the need for countermeasures to address these diseases during disasters.
Co-Authors Ali, Mazen EI. Eleojo , Itodo G. Enitan, Seyi S. Ghifari, Muhammad H. Jung, Yoonju Khansa, Firyal Nasywa, Fiola Zaskia, Siti R.