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All Journal Journal of Physics and Its Applications
Jonathan, Felix
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Astronomy Earth & Planetary Sciences Materials Science & Nanotechnology Physics

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Carboxymethyl Cellulose-Stabilized Platinum Nanoparticles Synthesized by Pulsed Laser Ablation for Enhanced CT Scan Contrast Wahyuddin, Wahyuddin; Jonathan, Felix; Hidayanto, Eko; Khumaeni, Ali
Journal of Physics and Its Applications Vol 7, No 4 (2025): November 2025
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v7i4.29925

Abstract

This study demonstrates the performance of platinum nanoparticles (Pt NPs) as contrast agents for computed tomography (CT). Synthesized through pulsed laser ablation, Pt NPs were stabilized in carboxymethyl cellulose (CMC). In CT imaging evaluations, the CMC-stabilized Pt NPs generated significantly higher Hounsfield Unit (HU) values and contrast-to-noise ratio (CNR) than both their DIW-based counterparts and a conventional iodine-based agent. Remarkably, this enhanced contrast was achieved at substantially lower ppm concentrations, highlighting the potential of CMC-stabilized Pt NPs to offer a more efficient and powerful alternative to current clinical standards.
Co-Authors Ali Khumaeni Eko Hidayanto I Ketut Sudiarta Wahyuddin Wahyuddin