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All Journal Jurnal Abdi Insani JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Buana, Belva Bhadranitya
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Public Health

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BEDAQUILINE SEBAGAI TATALAKSANA MULTIDRUG-RESISTANT TUBERCULOSIS (MDR-TB): SEBUAH KAJIAN SISTEMATIS DAN META ANALISIS Buana, Belva Bhadranitya
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 2 (2024): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 2 Periode O
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i2.554

Abstract

ABSTRAK Background: MDR TB is TB that is resistant to at least 2 types of first-line anti-tuberculosis drugs, namely isoniazid and rifampicin. Treatment requires a longer duration and is accompanied by worse side effects, high costs, and logistical constraints. Bedaquiline (BDQ) is a diarylquinoline compound which exhibits earlier culture conversion and minimal side effects, compared to other MDR TB drugs, making it possible to eliminate adherence problems in MDR TB patients. This meta-analysis aims to assess the effect of BDQ administration on MDR TB patients and other related aspects. Methods: Systematic studies were carried out following the PRISMA rules using online databases, namely PubMed, ScienceDirect, and Cochrane. Studies assessing the effect of BDQ in MDR TB patients and compliance with inclusion criteria were included in this systematic review. The risk of bias of each inclusion study was assessed using the CONSORT, TREND and STROBE criteria. Meta-analysis with the fixed-effects method was then performed to obtain the combined Mean Difference (MD) of all inclusion studies along with the 95% Confidence Interval (CI). Discussion: 17 studies involving 2454 patients were included in this systematic review. It was found that administration of BDQ in MDR TB patients increased the likelihood of conversion culture becoming negative with an RR of 1.39 (95% CI = 1.26-1.53 ; I2 = 29% ; p <0.00001), and decreased the likelihood of relapse with RR of 0.40 (95% CI = 0.21-0.75 ; I2 = 0% ; p = 0.004) significantly compared to the control group. As well as being able to reduce the death rate from MDR TB. Conclusions: BDQ administration showed a positive effect on the possibility of earlier culture conversion, the possibility of relapse, and the mortality rate
PROMOSI KESEHATAN TERKAIT IMUNISASI DASAR DALAM RANGKA MENINGKATKAN PEMANFAATAN PELAYANAN IMUNISASI ANAK PADA MASA PANDEMI Warnaini, Cut; Nurbaiti, Lina; Buana, Belva Bhadranitya
Jurnal Abdi Insani Vol 11 No 1 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i1.924

Abstract

The COVID-19 pandemic has caused various aspects of life in the world to experience quite drastic changes, especially health aspects. Studies show that there has been a decrease in the number of immunization services in health facilities by 84% as a result of the pandemic and the Large-Scale Social Restrictions (PSBB) policy implemented by the government. In many countries, low immunization coverage can be caused by several factors, including geographic barriers that cause disparities between urban and rural areas. A study found much lower vaccination rates in children living in rural areas compared to urban areas. This inequality in vaccine coverage rates can be overcome, one of the ways is by increasing knowledge about vaccines. This activity aims to increase community capacity regarding basic immunization programs during the pandemic. It is hoped that the results of this activity can act as a basis for consideration for regional and national policy making regarding health promotion and education in order to increase community capacity in the context of basic immunization programs. The outreach activity was held at the Narmada Community Health Center, West Lombok Regency in September 2021. Participants in the activity were the local community consisting of mothers of productive age who were either pregnant or planning to become pregnant, midwives and local community leaders. However, due to the second wave of COVID-19, the activity mechanism was facilitated through digital media. The enthusiasm of the activity participants was so good that the number of participants exceeded the initial target. Activity participants watched educational videos and were able to master the material presented well. This is proven by an increase in the post test scores obtained by participants compared to the pre test scores. Apart from that, through this activity five educational video episodes were produced with various themes related to basic immunization during the pandemic which were distributed via the YouTube channel. The activity succeeded in increasing community capacity regarding basic immunization programs during the pandemic. This will be the basis for the team's consideration in making recommendations for regional and national policies regarding health promotion and education in order to increase community capacity in the context of basic immunization programs.
Co-Authors Cut Warnaini Lina Nurbaiti, Lina