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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ
Suyono Saputri, Alip desi
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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A PENGUJIAN KADAR SENYAWA FLAVONOID EKSTRAK TERPURIFIKASI KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Sukmasnastiti, Messty; Suyono Saputri, Alip desi; Sa'ad, Muhammad
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 1 (2024): Volume 7, No 1, Tahun 2024
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i1.48144

Abstract

Masyarakat Indonesi banyak yang mengonsumsi buah naga merah (Hylocereus polyrhizus) karena rasanya yang enak dan bermanfaat untuk kesehatan serta harganya yang ekonomis. Kulit buah naga merah (Hylocereus polyrhiz) memiliki banyak khasiat antara lain sebagai antioksidan dan imunomodulator. Salah satu kandungan senyawa sekunder yang terdapat pada kulit buah naga adalah flavonoid. Tujuan penelitian ini yaitu mempurifikasi ekstrak kental etanol 96% dan melakukan penetapan kadar. Metode yang digunakan dalam penelitian ini yaitu metode maserasi dengan etanol 96% yang dilakukan selama 5 hari, purifikasi ekstrak kental hasil dari maserasi dengan pelarut etil asetat. Kemuadian dilakukan analisis kuantitatif dengan spektrofotometri UV-Vis. Analisis kuantitatif penetapan kadar flavonoid total ekstrak terpurifikasi menggunakan spektrofotometri UV-Vis diperoleh panjang gelombang 430 nm dan Operating Time 27 menit dengan menggunakan baku kuersetin. Berdasarkan hasil penelitian penetapan kadar flavonoid total ekstrak terpurifikasi kulit buah naga merah (Hylocereus polyrhiz) yaitu sebesar 69,164 ± 0,0403 mgQE/g ekstrak (6,92 ± 0,01%). Kata kunci: Kulit buah naga merah, ekstrak purifikasi, spektrofotometri UV-Vis, kadar flavonoid
Uji Fitokimia Dan Aktivitas Antibakteri Ekstrak Dan Fraksi Daun Suji (Dracaena angustifolia Roxb.) Pada Bakteri Staphylococcus aureus ATCC 25923 suyono saputri, alip desi
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.65891

Abstract

Staphylococcus aureus is the bacteria that causes the most cases of infection in the world. Most infectious disease therapy in Indonesia uses antibiotics. Incorrect use of antibiotics can increase resistance. One of the plants that has the potential as an alternative treatment for infections is suji leaves. The purpose of this study was to determine the potential of suji leaf extract and fraction on antibacterial activity in Staphylococcus aureus ATCC 25923 bacteria. Samples were extracted using the maceration method with 70% ethanol solvent and then fractionated using n-hexane, ethyl acetate, and water solvents. Phytochemical tests were carried out to determine alkaloids, flavonoids, tannins, saponins, polyphenols, triterpenoids and steroids. Antibacterial activity tests of suji leaf extracts and fractions were carried out using the well method at concentrations of 5%, 10%, and 15% respectively with a negative control of 70% ethanol and a positive control of ciprofloxacin. Suji leaf extracts and fractions contain alkaloids, flavonoids, tannins, saponins, steroids, and polyphenols. The extract, n-hexane fraction, and ethyl acetate fraction of suji leaves have antibacterial activity against Staphylococcus aureus ATCC 25923 bacteria. The inhibitory activity against Staphylococcus aureus ATCC 25923 bacteria was greatest in the ethyl acetate fraction at a concentration of 15% with an average inhibition zone of 19.6 mm but was not equivalent to the inhibition of the positive control ciprofloxacin
Co-Authors Sa'ad, Muhammad Sukmasnastiti, Messty