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All Journal Biology, Medicine, & Natural Product Chemistry Women Midwives and Midwifery
Kaur, Inderjeet
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Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Targeting H3N2 Influenza Virus RNA-dependent RNA Polymerase by Using Bioactives from Essential Oils from Eucalyptus polybrachtea, Cymbopogon citratus and Cymbopogon khasianus Sharma, Arun Dev; Kaur, Inderjeet
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.515-524

Abstract

A dramatic surge of H3N2 influenza virus is of grave concern worldwide and particularly in India. H3N2 cause acute respiratory infection, however, a few drugs are available for its mitigation. Subsequently, researchers have been involved in efforts to discover novel antiviral mechanisms that can lay the basis for new anti-influenza drugs. Influenza virus RNA-dependent RNA polymerase (RdRP) is a multi-functional hetero-trimer, implicated in the production of viral mRNA, hence plays a major role in viral infectivity thus directly associated with survival of the virus. RdRP have been cited as anappropriate target for therapeutic drug design. In the present study molecular docking was designed to estimate the effect of potent bioactive moleculesfrom essential oils from Eucalyptus polybrachtea (eucalyptus oil, EO), Cymbopogon citratus (lemon grass essential oil, LEO) and Cymbopogon khasianus (palmarosa essential oil, PEO) against RdRP protein. GC-FID (gas chromatography with flame-ionization detection) based composition profile, and in-silico docking study was conducted by using CB-dock 2 analysis followed by 2D interactions. GC-FID revealed eucalyptol, geranial and geraniolas major phytocompounds in EO, LEO and PEO respectively. The docking score indicated effective binding of ligands to RdRP. Interactions results indicated that, RdRP/ligand complexes form hydrogen, van der waals forces, pi-alkyl, alkyl, and pi-Sigma interactions. Based on above findings of aroma profile and docking, therefore, it was recommended that essential oils from above mentioned aromatic cropsmay represent potential herbal treatment to mitigate H3N2 infections.
Pregnancy and Pandemic: Impact of Covid-19 on Maternity Care and Psychosocial Well-Being of Pregnant Women in India Thota, Sowmya; Reddy, Radha; Kaur, Inderjeet; Loughnan, Siobhan; Gautam, Rupesh; Reddy, Gopireddy Murali Mohan
Women, Midwives and Midwifery Vol. 5 No. 2 (2025): Women, Midwives and Midwifery journal
Publisher : Asosiasi Pendidikan Kebidanan Indonesia (AIPKIND)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36749/wmm.5.2.93-111.2025

Abstract

Background: The COVID-19 pandemic significantly disrupted maternity care and affected the psychosocial well-being of pregnant women in India. Purpose: This study examines the impact of COVID-19 on access to maternity care, psychosocial health, and information satisfaction among pregnant women in South India. Methods: A cross-sectional study was conducted in tertiary hospitals in South India between September 2020 and January 2021 as part of the global COCOON study. A convenience sample of 321 pregnant women receiving antenatal care participated in an online survey available in English and Telugu. Psychosocial well-being was assessed using validated scales: State-Trait Anxiety Inventory (STAI), Edinburgh Postnatal Depression Scale (EPDS), Perceived Stress Scale (PSS-4), and De Jong Gierveld Loneliness Scale (DJGLS). Results: Despite the pandemic, 87.2% of women continued attending antenatal check-ups. However, 44% reported moderate-to-severe anxiety, 52% experienced depressive symptoms, 91% had high stress levels, and 82% felt lonely. Additionally, domestic violence increased by 10%, while 58% of participants reported strengthened family connections. Healthcare providers emerged as the most trusted information source (79%). Conclusion: "Despite continued access to maternity care, the pandemic significantly impacted the psychosocial well-being of pregnant women. Integrating routine mental health screening and support into antenatal care is crucial to improving maternal well-being and ensuring resilient maternity services during public health emergencies."
Co-Authors Gautam, Rupesh Loughnan, Siobhan Reddy, Gopireddy Murali Mohan Reddy, Radha Sharma, Arun Dev Thota, Sowmya