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Crystalia, Audrey Amira
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

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A Review on the Antimicrobial Properties of Giant Barrel Sponge- Xestospongia sp. Hartiadi, Leonny; edny, gisella; Rebecca, Jeannifer; Sheryl, Sheryl; Crystalia, Audrey Amira
Indonesian Journal of Life Sciences 2020: IJLS Vol 02 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (578.782 KB) | DOI: 10.54250/ijls.v2i2.55

Abstract

Indonesia sits in the heart of the largest biodiversity hotspot -Indo-Pacific region. Indonesia has access to endless resources of bioactive compounds from marine animals and plants. Marine sponges have been extensively studied over the years due to their nature of being exposed to various microorganisms. Xestospongia sp. establishes a symbiotic relationship with diverse microorganisms, leading to the synthesis of abundant bioactive resources which capable of inhibiting the growth of pathogenic bacteria. Publications from the last ten years were retrieved from PubMed and included in this review article. Bioactive compounds produced by Xestospongia sp. were effective in inhibiting gram-negative bacteria- P. aeruginosa, A. baumanii, E. coli, K. pneumoniae, P. aeruginosa, S. epidermis, S. typhi- and gram-positive bacteria -M. Intracellulare, S. aureus, S. pneumoniae, B. subtilis, V. anguaillarum. In addition, extracts were able to inhibit the growth of multidrug-resistance P. aeruginosa and methicillin-resistant S. aureus (MRSA). C. albicans, C. tropicalis, C. neofarmans, A. niger, Epidermophyton sp., M. gypseum, T. rubrum, T. mentagrophytes were susceptible to Xestospongia sp. extracts. The growth of chloroquine-resistant and susceptible strains of P. falciparum were inhibited by Xestospongia sp. with similar zones of inhibitions. The antimicrobial properties were contributed by the composition of chemically complex compounds such as phenolics, steroids and alkaloids; each of which exhibits a unique mechanism of action. The vast range of antimicrobial activity exhibited by Xestospongia sp. extracts implies their promising role in clinical settings for the treatment of infectious diseases including tuberculosis and malaria.
Anticancer Activity of Typhonium flagelliforme: A Systematic Review Crystalia, Audrey Amira; Hillary, Hillary
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (616.844 KB) | DOI: 10.54250/ijls.v4i1.99

Abstract

Cancer is a global health issues that can affect anyone. Cancer is treated conventionally with surgery, chemotherapy, radiotherapy, and hormone therapy. However, the high cost of conventional treatments is a burden for cancer patients. Therefore, many cancer patients seek for cheaper yet effective alternative treatments. Typhonium flagelliforme is a taro-like plant that can be found across Indonesia. Numerous researches on the anticancer effect of T. flagelliformehave been conducted. However, a systematic review on the anticancer property of T. flagelliforme is still lacking. Therefore, this review aimed to systematically evaluate the scientific evidence for the anticancer activities in T. flagelliforme. Five databases were used as the search engine using the designated search terms and studies were selected based on the inclusion criteria. The anticancer evaluation in 30 studies selected were conducted in leukemia, lymphoma, breast, oral, cervical, lung, liver, colon, and squamous cell carcinoma. The result showed that T. flagelliforme could inhibit cancer cell proliferation with most of the IC50 are less than 200 μg/mL. T. flagelliformeinduced an increase of caspase-3 and -9, as well as a decrease of the anti-apoptotic Bcl-2 protein expression. The expression of p21 protein was increased after treatment of T. flagelliforme extract while the tyrosine kinase, Ki67, HER2/neu, telomerase, and COX-2 expressions were decreased implying T. flagelliforme could inhibit tumor growth and development. Lastly, T. flagelliforme is also capable in reducing the possibility of cancer cell invasion. Findings suggest that T. flagelliforme is potential to further developed for cancer treatment.
A Review on Pharmacological Activity of Monarda fistulosa L. Wahyudi, Berthalia Marshella; Chung, Cecilia Ashley; Chelovna, Celine; Soetanto, Fenny; Anggasta, Giovanni; Zafira, Qastalia; Maulida, Nurul Fajry; Crystalia, Audrey Amira
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v4i2.142

Abstract

Monarda fistulosa is a plant often used in traditional medication with numerous benefits. This review paper aims to elaborate on the phytochemicals of Monarda fistulosa that contribute to its pharmacological activity. Numerous studies have found the bioactive compounds of Monarda fistulosa including carvacrol, thymol, thymoquinone, flavonoid, ????-pinene, caryophyllene oxide, limonene, and geraniol. Researchers have found several pharmacological activities in relation to these compounds including antimicrobial, antidiabetic, anticancer, anti-inflammatory, antioxidants, and immunomodulatory properties. Evidence shows that Monarda fistulosa has potential for applications in many areas. Nevertheless, further clinical studies still have to be conducted to assess the effects of this plant.
Effect of Pressurized Blanching Time on Antioxidation Properties of Curcuma xanthorrhiza Roxb. Powder with Various Solvents Astuti, Devi Fitri; Pujimulyani, Dwiyati; Kanetro, Bayu; Crystalia, Audrey Amira; Windrayahya, Sulkhan
agriTECH Vol 45, No 3 (2025)
Publisher : Faculty of Agricultural Technology, Universitas Gadjah Mada, Yogyakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/agritech.90728

Abstract

Javanese turmeric (JT) or Curcuma xanthorrhiza Roxb. is rhizome possessing bioactive components such as curcuminoids and xanthorrizhol that are soluble in various solvents. Therefore, this study aimed to evaluate the antioxidation properties of JT extract with various solvents for extraction. The method used was a Completely Randomized Design (CRD), with variations of pressure blanching time (0, 2.5, 5; 7.5, and 10 minutes) and solvents (80% methanol, 80% ethanol, and 80% acetone). Antioxidation properties were determined comprising antioxidant activity (DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (Ferric Reducing Antioxidant Power), phenol, flavonoid, β-carotene, curcumin, and tannin. The results showed that at a pressurized blanching time of 5 minutes, JT extract had the highest antioxidant activity. By using DPPH and FRAP methods with 57.31% RSA and 7.91 mg Ferro E/g, the highest antioxidant activity was also obtained in 80% ethanol solvent. Furthermore, phenol, flavonoid, β-carotene, tannin, and curcumin contents were 48.70 mg GAE/g, 7.28 mg QE/g, 243.83 μg/g, 2.44 ppm and 1.81%, respectively. This study showed that JT subjected to pressurized blanching had higher antioxidant activity than the fresh sample.
Co-Authors Anggasta, Giovanni Astuti, Devi Fitri Bayu Kanetro Chelovna, Celine Chung, Cecilia Ashley Dwiyati Pujimulyani edny, gisella Hartiadi, Leonny Hillary, Hillary Maulida, Nurul Fajry Rebecca, Jeannifer Sheryl, Sheryl Soetanto, Fenny Wahyudi, Berthalia Marshella Windrayahya, Sulkhan Zafira, Qastalia