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All Journal Current Research on Biosciences and Biotechnology Indonesian Journal of Life Sciences
Siswanto, Melinda
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Implementation of Biodesign process to Identify Unmet Needs of Tuberculosis Patients in Indonesia Siswanto, Melinda; Thimoty, Gabriella; Bera, Jonathan Hendrik
Indonesian Journal of Life Sciences 2021: IJLS Vol 03 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.595 KB) | DOI: 10.54250/ijls.v3i1.123

Abstract

Tuberculosis (TB) is an infectious disease mainly caused by Mycobacteria tuberculosis. It affects the respiratory system and may spread to the other organ. Due to the nature of the bacteria, infection of this species may cause a long-term TB, causing it a challenge for a full clearance. The disease has existed throughout the history, and BCG vaccine has been developed to control the spreading. Most developed countries have successfully eradicated TB. However, Indonesia is currently ranked second place for this disease, making it as a pressing matter to eradicate. This study is conducted to investigate and gather deep insights about the problems in eradicating TB in Indonesia. Identify part of the biodesign method is employed in the study to elucidate the complexity of healthcare issue of TB in Indonesia. The study discovered that there are three pillars’ sectors need to be addressed: education, healthcare facilities and services, and government. For successful eradication, synergistic approach to all pillars at the same time are essential. The needs statements formulated in this study could be the stem of innovation in TB.
Investigating the types and mechanisms of Mycobacterium tuberculosis resistance: why Indonesia continues to experience high case rates compared to other nations Siswanto, Melinda; Kusnadi, Angelica Laura; Armevia, Nandya Zahra; Agustin, Regita
Current Research on Biosciences and Biotechnology Vol. 6 No. 2 (2025)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2025.6.2/CUYYSK0G

Abstract

Tuberculosis (TB) cases in Indonesia have been a major issue in public health. Although antimicrobial therapies such as Isoniazid and Rifampicin are available, Indonesia still struggle to control its spread and yet to eradicate the infection. This is due to the resistance developed by Mycobacterium tuberculosis, the main cause of TB, causing an increasing number of Extensively Drug-Resistant Tuberculosis (XDR-TB). This problem exacerbates by the inadequacy of healthcare infrastructure to effectively detect and treat TB. Hence, this study is established to address the challenges and strategies for controlling TB and XDR-TB in Indonesia. The analysis involves epidemiological studies, genetic research, and public health policy reviews to identify the factors contributing to TB drug resistance and to propose targeted interventions. The findings reveal that high drug resistance and inadequate healthcare infrastructure are major barriers. Evidence-based interventions and enhanced diagnostic capacity are crucial for controlling TB in Indonesia. Socioeconomic factors like poverty and limited access to healthcare services also influence the spread of TB in Indonesia. Improving the healthcare system and addressing socioeconomic issues can help reduce TB and XDR-TB rates.
Co-Authors Agustin, Regita Armevia, Nandya Zahra Bera, Jonathan Hendrik Kusnadi, Angelica Laura Thimoty, Gabriella