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All Journal The International Science of Health Journal
Ghasaq Farouq Hammeed
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Modification of Sulfadiazine Antibacterial to Promising Anticancer Schiff Base Derivatives: Synthesis and in Vitro Studies Tasnim Tariq Mohammed; Aula Hassoon Obaid; Ghasaq Farouq Hammeed; Abbas K. Abbas
The International Science of Health Journal Vol. 2 No. 3 (2024): September: The International Science of Health Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesdam IV, Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ishel.v2i3.1259

Abstract

The study displays a novel approach for synthesizing imine-sulfadiazine compounds (A and B) by reacting Sulfadiazine with various aldehydes, including 2-chlorobenzaldehyde and 4-pentoxybenzaldehyde. The derivatives (A and B) were characterized using spectroscopic techniques, specifically FT?IR spectroscopy. The synthesized compounds were assessed in vitro against various bacteria, including Streptococcus pneumoniae and E. coli, using the zone inhibition method. The results indicated that specific derivatives possess enhanced antibacterial characteristics compared to the effectiveness of the regular medications. The derivative A was assessed for its anticancer activity against breast cancer MCF-7 cells using the MTT assay, which yielded a favorable outcome within 24 hours.  
Co-Authors Abbas K. Abbas Aula Hassoon Obaid Tasnim Tariq Mohammed