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All Journal JHeS (Journal of Health Studies) Jambura Medical and Health Science Journal
Fa'izah, Chintya Nur
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Humanities Education Health Professions Medicine & Pharmacology Nursing Public Health

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Deep Brain Stimulation for Alzheimer’s Disease: A Review of a Potential Treatment in Neurosurgery Husodo, Kharisma Ridho; Fa'izah, Chintya Nur
Jambura Medical and Health Science Journal Vol 3, No 1 (2024): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v3i1.23340

Abstract

Background: Alzheimer’s disease (AD) is still a disease with abundant enigma. Moreover, the prevalence of AD increases every year by about 10 million new cases. This disease is well known for its degenerative feature with age being the most influencing factor. Pathophysiologically, the deposition of beta-amyloid and tau proteins is the culprit for disrupting the neural connections in the brains of AD patients. Some studies have stated that drug medications are not effective in treating AD patients.Content: Currently, there is no drug to cure the disease. In conditions in which drugs fail to take effect, there is a therapy called deep brain stimulation (DBS), which allows the brain to be stimulated electrically using electrodes that are implanted into certain brain areas as targets. In AD patients, the nucleus basalis of meynert (NBM) and fornix are frequently selected as targets in DBS. This intervention is performed surgically by the neurosurgeon. Several potential mechanisms of this treatment include controlling connections among neurons, decreasing beta-amyloid and tau protein levels, and inhibiting the inflammation process in the brain.Conclusion: DBS can improve AD patients, both clinically and molecularly. Despite the promising effects of DBS, this treatment has limitations, so it cannot be applied to every patient with AD.
Acute kidney injury as a prognostic factor in traumatic brain injury: rotterdam score association Fa'izah, Chintya Nur; Husodo, Kharisma Ridho
JHeS (Journal of Health Studies) Vol. 9 No. 1 (2025): Maret
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhes.4207

Abstract

Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide, affecting nearly 50 million people annually. Acute kidney injury (AKI) is a potential complication in critically ill patients, but its relationship with TBI severity remains unclear. This study aimed to assess the association between AKI, Rotterdam score, length of stay (LOS), and outcomes in TBI patients. A cross-sectional study was conducted using medical records of TBI patients admitted to Yogyakarta Islamic Hospital PDHI from 2019 to 2022. Inclusion criteria were age 15–65 years, confirmed TBI diagnosis, head CT scan, and completed hospital treatment. Patients with pre-existing kidney disease, direct renal trauma, shock, or other AKI-related factors were excluded. Rotterdam scores were obtained from radiologist reports. Statistical tests assessed associations between AKI and clinical variables. Seventy-two patients met the criteria; 26.4% developed AKI. Higher Rotterdam scores (4–6) were significantly associated with AKI (p = 0.026). No significant association was observed between AKI and LOS (p = 0.393). AKI was strongly associated with poor outcomes (p = 0.004), with mortality rates of 26.3% in AKI patients compared to 1.9% in non-AKI patients. Higher Rotterdam scores may indicate increased AKI risk in TBI patients, and AKI is associated with markedly worse outcomes. Early recognition and management of kidney injury in high-risk patients may improve survival. Further prospective studies are needed to confirm these findings and explore preventive strategies.
Co-Authors Husodo, Kharisma Ridho