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Afifah, Farabillah
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Preventive Effect of Exercise on Kidney Fibrotic Pathway in Hypertension Afifah, Farabillah; Dewi Irawati Soeria Santoso
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 03 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss03/532

Abstract

Uncontrolled hypertension can progress to kidney damage characterized by structural and functional changes, ultimately contributing to kidney fibrosis. Although, hypertension can be treated. However, the prevalence of hypertension in Indonesia is increasing. Therefore, proper treatment is necessary. Elevated levels of Transforming Growth Factor-β1 and Connective Tissue Growth Factor are critical factors that are key drivers of fibrogenic pathway. Appropriate exercise can control blood pressure, renal function, and prevent kidney fibrosis due to hypertension by activating the nitric oxide signaling pathway and reducing the regulation of the TGF-β, p-Smad2/3 and CTGF. This study aims to determine the optimal type of exercise to prevent kidney fibrosis caused by hypertension. Articles used are limited to the publication year between 2018 and 2024. We analyzed the role of exercise on kidney fibrotic pathway in hypertension using PRISMA methods from PubMed, ScienceDirect, Scopus, and Google Scholar. We found 7 articles and proved several significant effects of exercise on hypertension subjects. This study summarized that moderate-intensity exercise is more influential in controlling blood pressure and renal function, as well as inhibits kidney fibrosis due to hypertension.
The Relationship Between Probiotic Intake and Glycemic Profiles Among Metformin-Treated Type 2 Diabetes Patients Larasati, Rahma Ayu; Silviah; Afifah, Farabillah; Aniyah, Siti Hadzul
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 01 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss01/648

Abstract

The ideal management of Type 2 Diabetes Mellitus should evolve from mere glucose-lowering strategies to a more comprehensive framework encompassing personalized medicine, technological integration, and systemic organ protection. A significant number of patients with Diabetes Mellitus (DM) continue to suffer from mortality and serious complications despite being on pharmacological therapy. Although trillions of dollars are spent annually on its management, diabetes remains a leading cause of mortality, claiming millions of lives each year across the globe. Probiotics have been proposed as an adjunctive therapy due to their role in modulating gut microbiota and glucose metabolism. This study aimed to analyze the effect of probiotic supplementation on Fasting Blood Sugar (FBS) levels in T2DM patients receiving metformin monotherapy. This experimental study involved 32 respondents, divided into probiotic intervention and placebo groups. FBS levels were measured pre- and post-intervention. Statistical analysis using the Paired T-Test showed a significant reduction in FBS levels (p=0.019). Conclusion: Probiotic supplementation significantly reduced FBS levels in T2DM patients on metformin monotherapy. However, this reduction was not clinically significant, as the final FBS levels did not differ significantly between the probiotic and placebo groups.  
Co-Authors Aniyah, Siti Hadzul Rahma Ayu Larasati Santoso, Dewi Irawati Soeria Silviah