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All Journal Open Access Indonesian Journal of Medical Reviews Scientific Journal of Pediatrics
Ratu Hanny Anggorowati
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Nephrotic Syndrome in Pediatrics: A Case Report Ratu Hanny Anggorowati; Huminsa Ranto Mourison Panjaitan; Andre Yusanto; Annisah, Rati
Scientific Journal of Pediatrics Vol. 1 No. 1 (2023): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v1i2.46

Abstract

Introduction: The prevalence of childhood NS worldwide is approximately 16 cases per 100,000 children, with an incidence of two to seven per 100,000 children. Primary causes of NS include minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, genetic disorders, and secondary diseases associated with infections, drugs, and neoplasia; however, it can also be idiopathic. Case presentation: A 14-year-old male toddler weighing 39 kg with a 1-week history of swelling around the eyes and both legs and generalized body swelling. On physical examination, swelling was found in both lower legs (pitting type). Laboratory investigations showed protein in urine and reduced serum albumin (2.0 g/dL) with elevated lipid levels. Although a kidney biopsy could not be performed due to the economic problem of the family, a diagnosis of idiopathic nephrotic syndrome (NS) was made based on clinical and laboratory findings. Conclusion: Nephrotic syndrome in children includes dietary adjustments, administration of diuretics to reduce edema, and administration of immunosuppressants such as steroids to induce remission.
Meta-Analysis of Novel Biomarkers for Early Diagnosis of Neonatal Sepsis Rati Annisah; Ratu Hanny Anggorowati
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 5 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i5.658

Abstract

Neonatal sepsis is a major cause of illness and death in newborns worldwide. Early diagnosis is critical for quick treatment and better outcomes. However, traditional markers like white blood cell count and immature-to-total neutrophil ratio are often not sensitive or specific enough. This meta-analysis reviewed PubMed, Embase, and the Cochrane Library from January 2013 to December 2023. It included studies that assessed the accuracy of procalcitonin (PCT), interleukin-6 (IL-6), and C-reactive protein (CRP) in diagnosing neonatal sepsis. The QUADAS-2 tool was used to check the quality of the studies. Six studies, including 1245 newborns, were analyzed. PCT had the highest pooled sensitivity (0.85, 95% CI 0.80-0.90) and specificity (0.82, 95% CI 0.75-0.89), followed by IL-6 (sensitivity: 0.78, 95% CI 0.70-0.85; specificity: 0.75, 95% CI 0.65-0.83). CRP was less sensitive (0.70, 95% CI 0.60-0.79) and specific (0.68, 95% CI 0.58-0.77). In conclusion, new biomarkers, especially PCT, are promising for early diagnosis of neonatal sepsis. However, more large-scale studies are needed to confirm these findings.
Co-Authors Andre Yusanto Annisah, Rati Huminsa Ranto Mourison Panjaitan Rati Annisah