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Role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in diagnosing neonatal sepsis Hasibuan, Beby S.; Dasatjipta, Guslihan; Lubis, Bugis M.; Sanny, Sanny
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.763

Abstract

Clinical manifestations of neonatal sepsis are often unspecified. Therefore, sepsis biomarkers could be used to support diagnosis while waiting for blood culture results, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). The aim of this study was to evaluate the role of NLR and PLR as diagnostic markers in neonatal sepsis. A cross-sectional study was conducted at Haji Adam Malik General Hospital, Medan, Indonesia, from April to October 2019. This study included neonates aged less than 28 days, diagnosed with suspected sepsis, and had no previous history of antibiotics administration. Patients underwent clinical assessment, laboratory examination, and blood culture. Patients were grouped into sepsis and non-sepsis based on the blood culture results. The median hematological examination and the range of NLR and PLR in both the sepsis and non-sepsis groups were subjected to analysis using the Mann-Whitney U test to assess differences. NLR and PLR optimal cut-off values were determined using a receiver operator curve (ROC) with a confidence interval of 95%. A total of 137 neonates were enrolled, of which 49 were classified as sepsis and 89 as non-sepsis based on blood culture results. The optimal cutoff values for NLR and PLR were 2.75 and 11.73. Using those cutoff values, NLR and PLR could predict neonatal sepsis with sensitivities of 52.1% and 47.9%, specificities of 50.6% and 47.2%, area under the curve (AUC) of 0.46 and 0.47, with p=0.525 and p=0.662, respectively. Further investigation is warranted to refine the NLR and PLR utility and enhance diagnostic accuracy in clinical practices.
Therapeutic Agreement Between Doctor and Patient: Juridical Analysis in Civil Law Aisyah, Aisyah; Prananda, Arya Tjipta; Dasatjipta, Guslihan; Afrita, Afrita
Ipso Jure Vol. 2 No. 5 (2025): Ipso Jure - June
Publisher : PT. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/8fnqed72

Abstract

The relationship between doctor and patient is not only ethical and professional, but also has a strong legal dimension, particularly in the form of therapeutic agreements. This agreement forms the basis for initiating medical proceedings and creates a binding legal relationship based on the principles of civil law. This study aims to analyze juridically the existence and validity of therapeutic agreements within the framework of civil law, examine the forms of legal liability arising from violations, and evaluate evidentiary instruments in medical disputes. The method used is normative legal research with a legislative approach, supported by an analysis of legal literature and jurisprudence studies. The results of the study show that although therapeutic agreements are often not stated in writing, their existence is still valid and binding if they meet the legal requirements of the agreement as stipulated in Article 1320 of the Civil Code. Informed consent serves as proof of the implementation of the agreement and as the basis for legal defense in disputes. Civil liability can be imposed both on doctors personally and hospitals as institutions through the doctrine of vicarious liability, and forms of compensation include material and immaterial losses. Dispute resolution through non-litigation channels such as mediation and the role of the Indonesian Medical Discipline Honorary Council (MKDKI) also have an important contribution in maintaining a balance between patient protection and medical professional accountability.