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Hidayati, Citra A.
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Could fasciotomy prevent amputation in patients with electrical burn injuries? Insights from a cross-sectional study in Indonesia Hidayati, Citra A.; Saputro, Iswinarno D.; Hutagalung, Magda R.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.834

Abstract

The amputation rate resulting from electrical burn injuries remains high, yet no study has investigated whether early fasciotomy may reduce the amputation rate. The aim of this study was to analyze the success rate of fasciotomy in preventing amputation and determine the optimal timing for fasciotomy in electrical burn injuries. This study was conducted at Dr. Soetomo Hospital from January 2020 to July 2023. Total sampling was employed to recruit the patients. Clinical data, voltage characteristics, burn location, affected total body surface area, burn depth, hospital arrival time, and time interval from incident to fasciotomy were assessed. Chi-squared test was used to assess factors associated with the fasciotomy incidence and factors associated with amputation after fasciotomy. A total of 45 patients were included of which 97.8% were male with a mean age of 37.60-year-old. Approximately 73% of patients had full-thickness burn injuries, with the left upper extremity being the most affected (80%). There are seven patients (15.6%) had fasciotomy and five (11.1%) patients had an amputation. Our data indicated a significant association between voltage characteristics and fasciotomy incidence (p=0.034). Additionally, our data indicated that earlier arrival to the hospital (p=0.002) and timely fasciotomy conducted upon arrival (p<0.001) were associated with a reduced rate of amputation. This study highlights that prompt arrival to the hospital and early fasciotomy may prevent amputation in patients with electrical burn injuries.
Can a combination of nanofat and freeze-dried human amniotic membrane enhance full-thickness wound healing? An animal study using rabbit models Hidayati, Citra A.; Saputro, Iswinarno D.; Budi, Agus S.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1157

Abstract

Previous studies have explored nanofat stimulating tissue regeneration and maturation, promoting remodeling through its rich content of growth factors and stem cells; however, comprehensive data on its use in full-thickness wounds remains limited. The aim of this study was to evaluate the effectiveness of combining nanofat with freeze-dried human amniotic membrane (FDHAM) for treating full-thickness wounds in a rabbit model. An animal experimental study using a post-test control group design was conducted. Thirty-six male New Zealand white rabbits (Oryctolagus cuniculus) were randomly assigned to two groups: the experimental group (received a combination of nanofat and FDHAM) and the control group (received FDHAM alone). Each group was subdivided to evaluate effects on days 3 and 7. Macroscopic evaluations of wound healing, microscopic assessment of epithelialization and measurement of epidermal growth factor (EGF) levels in the wounds were conducted on days 3 and 7 post-injury. The present study indicated that the combination treatment significantly elevated EGF levels in the wounds on both days 3 and 7 (with p<0.001 for both assessment time points). The combination of nanofat-FDHAM did not significantly accelerate epithelialization on either day 3 or 7. This study highlights that combining nanofat with FDHAM did not significantly speed up epithelialization of full-thickness wounds within the first seven days; however, it notably increased EGF levels, suggesting that nanofat may enhance the wound's biological environment.
Co-Authors Budi, Agus S. Hutagalung, Magda R. Saputro, Iswinarno D.