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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Global Medical and Health Communication Jurnal Plastik Rekonstruksi
Jaya, Fidi Bhawana
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Civil Engineering, Building, Construction & Architecture Dentistry Health Professions Immunology & microbiology Neuroscience Nursing Public Health Other

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Moringa oleifera Lam. to accelerate wound healing: a review Jaya, Fidi Bhawana; Syamsunarno, Mas Rizky Anggun Adipurna; Sahiratmadja, Edhyana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202310

Abstract

An injury to the skin that disrupts the soft tissue may form a wound. The healing process in response to injury is a dynamic and well-regulated process of cellular, humoral, and molecular mechanisms that consists of four partly overlapping phases: hemostasis, inflammation, proliferation, and remodeling. An impaired wound-healing process may cause a formation of an abnormal scar and chronic wounds, leading to a reduced life quality. Therefore, it needs an optimal prevention strategy. Many modalities have been claimed to accelerate wound healing. The trend of using natural products is increasing in most Southeast Asian countries due to their biodiversity. Nowadays, studies on natural compounds are increasing to accelerate wound healing. Moringa oleifera Lam. is a high-value plant that each part of it has a high nutritional value as well as a great range of medicinal uses, including anti-inflammatory, antimicrobial, antioxidant, and wound healing properties. In this review, we have explored the M. oleifera that are very rich in vitamins, minerals, fatty acids, and phytochemical compounds like quercetin, kaempferol, and vicenin-2, that play a role in the wound healing process. Moreover, these compounds may enhance the healing of wounds with pathological conditions such as diabetes, immunocompromised and persistent infection.
Facial Soft Tissues Reconstruction Methods After Tumor Resection in Soedarso General Hospital 2017 - 2022 Jaya, Fidi Bhawana; Setiawan, Doni
Jurnal Plastik Rekonstruksi Vol. 10 No. 2 (2023): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v10i2.355

Abstract

Introduction: Facial contour deformity is a very challenging problem for aesthetic and reconstructive surgeons. Assessment of facial deformities is important for developing a subsequent reconstruction plan. Various techniques have been described for the repair of tumor-related defects of facial soft tissues. This study aimed to describe methods of Facial Soft Tissue Reconstruction after Tumor Resection at Soedarso General Hospital, West Kalimantan. Method: A retrospective descriptive study using data such as age, gender, type of tumor, size of the defect, and type of reconstruction done, which were collected from medical records of all patients with malignant facial soft tissue tumors who have underwent tissue reconstruction after tumor resection at Soedarso General Hospital, West Kalimantan, between 2017 and 2022. Result: A total of 48 patients were included. 33 patients underwent rotational flap only, 8 patients underwent rotational flap and skin graft, 1 patient underwent transposition flap, 6 patients underwent skin graft. 39 patients had BCC, 7 patients had SCC, 1 patient had MM, 1 patient had Meibom gland Adenocarcinoma. 25 patients were female, 23 patients were male. 41 patients had age 60 years old and older, 7 patients had age younger than 60 years old. 8 patients with defect size larger than 4x4x3 cm, 40 patients with defect size smaller than 4x4x3 cm. Conclusion: Knowledge of distribution patterns of facial soft tissue tumors will help to correctly choose the right options in facial reconstruction. Unawareness can lead to inadequate treatment with serious consequences for the affected patient.
Effect of Moringa Leave Ethanol Extract on Accelerating Wound Healing Process Jaya, Fidi Bhawana; Syamsunarno, Mas Rizky Anggun Adipurna; Sahiratmadja, Edhyana; Sulistiyorini, Ifa
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.11620

Abstract

TGF-β and VEGF are vital in cell proliferation and regeneration, as evidenced in processes like wound healing. The leaves of Moringa oleifera Lam exhibit anti-inflammatory and cell regenerative properties that may facilitate the transition from the inflammatory to the proliferative phase, enhancing wound repair. This research sought to discern the potential of orally administered moringa leaf extract in augmenting systemic wound healing, focusing on TGF-β and VEGF serum as in vivo molecular markers. This research was conducted at the Animal Laboratory of the Faculty of Medicine, Universitas Padjadjaran, and the Laboratory of Molecular Genetics, Universitas Padjadjaran, from January to March 2022. We divided thirty Swiss Webster mice into two categories: healthy and wound-treated. Wounded mice received 100 mg/kgBW Na CMC as a negative control, 500 mg/kgBW zinc syrup as a positive control, and M. oleifera leaves ethanol extract (MOLE) in doses of 280 and 560 mg/kgBW orally from day 3 to day 6. Wound progression was documented and measured on days 0, -1, -3, and -6. Day-6 blood samples were obtained, and TGF-β and VEGF serum levels were gauged using ELISA. Results from day 6 revealed that wound coverage in the 280 and 560 mg/kgBW MOLE groups was 13.76±5% and 13.38±4%, respectively. These percentages notably surpassed that of the negative control group (p=0.005). However, the TGF-β and VEGF serum levels in the MOLE-treated groups did not differ significantly from the negative control (p=0.081 and p=0.149, respectively). Thus, the study concludes that while MOLE expedites wound closure, it does so without the systemic involvement of TGF-β and VEGF in vivo.
Co-Authors Doni Setiawan Edhyana Sahiratmadja Mas Rizky A.A. Syamsunarno Sulistiyorini, Ifa