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All Journal MEDICINUS Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
Supriyanto Kartodarsono
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Pengaruh Pemberian Produk Olahan Kacang Kedelai terhadap Glukosa Darah Puasa dan Resistansi Insulin pada Model Tikus Diabetes Melitus Kendra Hosea; Supriyanto Kartodarsono; Arifin; Sumardi
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.102

Abstract

Background: Diabetes mellitus (DM) is a chronic condition that requires continuous medical care with multifactorial management strategy. Soybean is known as source of isoflavones that possess beneficial effect to help controlling blood glucose level. This study aims to evaluate the effect of soybean product diet to reduce fasting blood glucose and improve insulin resistance. Methods: This is an experimental study using 30 streptozotocin-induced diabetic Wistar rats that divided into 5 groups, i.e. normal rats, negative control, and three treatment groups that receive tempeh, tofu, and soy flour diet for 2 weeks. Fasting blood glucose was tested before treatment, after diabetes induction, and at the end of the study. HOMA-IR was calculated using fasting blood glucose and fasting insulin level after diabetes induction and at the end of the study. MANOVA test was used to analyzed the data statistically (p<0,05). Results: There was a significant effect from soybean product diet (tempeh, tofu, and soy four) in reducing fasting blood glucose and HOMA-IR, with slightly better result shown in tempeh group. Conclusion: Soybean product such as tempeh, tofu, and soy flour have beneficial effect in reducing fasting blood glucose and improving insulin resistance in streptozotocin-induced diabetic rats.
Fibrocalculous Pancreatic Diabetes (FCPD): A Rare Type of Pancreatogenic Diabetes Ega Caesaria Pratama Putra; Eva Niamuzisilawati; Yulia Sekarsari; Brilliant Van Fitof Songso Rhomado; Supriyanto Kartodarsono
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 2 No. 2 (2025): InaJEMD Vol. 2, No. 2
Publisher : PP PERKENI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66266/inajemd.v2i2.68

Abstract

FCPD is a rare form of secondary diabetes. FCPD is mainly found in the tropical region; it is characterized by diabetes, chronic abdominal pain, calcification of the pancreas, and steatorrhea. The Incidence of FCPD is often misdiagnosed with type 2 or type 1 diabetes mellitus. A 46-year-old man came with chief complaints of chronic abdominal pain. Abdominal radiography showed calcification in the pancreas. The patient was malnourished. Abdominal X-ray revealed pancreatic calcification, which was confirmed by an abdominal MSCT scan. C-Peptide decreased with an intermediate degree. The patient was given supportive therapy,and insulin was given to control his diabetes. FCPD is a morphological pancreas change caused by chronic tropical pancreatitis. The aetiology of chronic tropical pancreatitis is unknown. FCPD can be diagnosed by history taking and supporting examinations such as abdominal X-ray examination, ultrasound and abdominal CT Scan. C-peptide was examined to assess the function of pancreatic beta cells. The primary treatment for FCPD is insulin therapy; metformin or Sulfonylureas can be used in the early phase of diabetes. In reducing pain, non-steroidal analgesics are used as an option. The use of pancreatic enzyme supplementation can improve the nutritional status of patients. FCPD is a rare case, occurring mainly in tropical countries and in people who are malnourished. The primary treatment for FCPD is insulin therapy.
Co-Authors Arifin Brilliant Van Fitof Songso Rhomado Ega Caesaria Pratama Putra Eva Niamuzisilawati Kendra Hosea Sumardi Yulia Sekarsari